The new mechanism in the development of polycystic kidney～the role of PTEN and EGF receptor in the proximal tubule～

多囊肾发生发展的新机制～近端管中PTEN和EGF受体的作用～

• 批准号: 21890170
• 负责人: 長井 幸二郎
• 金额: $ 1.66万
• 依托单位: The University of Tokushima
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890170/
• 关键词: PTEN; EGF受容体; 多発性嚢胞腎

The mechanism in the development of polycystic kidney is still unclear. We developed the proximal tubule specific PTEN knockout mice and found the development of polycystic kidney. We investigated the proliferation and apoptosis in the proximal tubule and the proliferation can be the main factor of the cyst formation. We also checked the cilia and the number and the length of the cilia were not different from control mice. To clarify the role of the EGF receptor in the cyst formation, we started to establish PTEN-EGF receptor double knockout mice in the proximal tubule. Now, we are choosing the effective line to develop the double knockout.

多囊肾发生发展的机制尚不清楚。我们建立了近端小管特异的PTEN基因敲除小鼠，发现了多囊肾的发育。我们研究了近端小管的增殖和凋亡，增殖可能是囊变形成的主要因素。我们还检查了纤毛，纤毛的数量和长度与对照组小鼠没有差异。为了阐明EGF受体在包囊形成中的作用，我们开始在近端小管建立PTEN-EGF受体双基因敲除小鼠。现在，我们正在选择有效的路线来发展双淘汰赛。

项目成果

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Multiple cyst formation in PTEN conditional knockout mice in kidney.

PTEN 条件性敲除小鼠肾脏中多个囊肿的形成。

• 发表时间: 2008
• 作者: Shusaku Uchida;et. al;長井幸二郎
• 通讯作者: 長井幸二郎