Epigenetic regulation of pancreatic beta cell function by Pdx1 transcription factor complex

Pdx1转录因子复合物对胰腺β细胞功能的表观遗传调控

• 批准号: 22890027
• 负责人: ARAKI Osamu
• 金额: $ 1.96万
• 依托单位: Gunma University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890027/
• 关键词: 糖尿病; 膵β細胞; 転写因子; エピジェネティクス; 発現制御

Pancreatic duodenal homeobox-1 protein (Pdx1) is a transcription factor that plays a critical role in the regulation of pancreatic islet development and insulin gene expression. This study aimed to identify Pdx1 transcription factor complex and characterize its physiological roles in the regulation of insulin gene transcription and epigenetic control of mature beta cell function. The results of this study lead to exploring the underlined mechanism of beta cell failure in diabetes, and identifying the epigenetic hallmark for mature functioning beta cells useful for the characterization of beta cell differentiation and regeneration.

胰腺十二指肠同源盒-1蛋白(Pdx1)是一种转录因子，在调节胰岛发育和胰岛素基因表达中起关键作用。本研究旨在鉴定Pdx1转录因子复合体，并研究其在胰岛素基因转录调控和成熟β细胞功能表观遗传调控中的生理作用。这项研究的结果导致探索糖尿病中β细胞衰竭的强调机制，并确定有助于表征β细胞分化和再生的成熟功能β细胞的表观遗传学标志。

项目成果

Association between accumulation of visceral fat and the combination of β 3adrenergic receptor Trp64Arg, β 2adrenergic receptor Arg16Gly and uncoupling protein 1-3826A>G polymorphisms detected by Smart Amplification Process 2

Smart Amplification Process检测到的β3肾上腺素受体Trp64Arg、β2肾上腺素受体Arg16Gly与解偶联蛋白1-3826A>G多态性结合与内脏脂肪堆积的关系2

• 发表时间: 2011
• 期刊: Endocr J
• 影响因子: 2
• 作者: Tsunekawa K;Yanagawa Y;Aoki T;Morimura T;Araki O;Ogiwara T;KawaiY;Mitani Y;Lezhava A;Yanagawa M;Hayashizaki Y;Murakami M
• 通讯作者: Murakami M

C/EBPα,PPARγを介した甲状腺ホルモンによる脂肪細胞分化誘導機構の解析

甲状腺激素通过C/EBPα和PPARγ诱导脂肪细胞分化的机制分析

• 发表时间: 2011
• 作者: Ishida;Y.;et al.;松田直正;荒木修
• 通讯作者: 荒木修