Kinetics of suppressor T cells in spontaneous tumor-bearing mice

在肿瘤形成前约两周，分泌IL-10和IL-17的γ δ T细胞在皮下3-MCA处理的小鼠的引流和非引流淋巴结的髓质和被膜下窦中爆发性扩增。先天性IL-10+ IL-17+ γ δ T细胞扩增的异常被证明与体循环的预防和淋巴结中的CD 107 a + CD 8+成熟CTL和CD 4 + Foxp 3 + Treg细胞的凋亡诱导相关。

IL-10- and IL-17-secreting gamma delta T cells expanded explosively in the medulla and subcapsular sinus of both draining and non-draining lymph nodes of subcutaneous 3-MCA-treated mice around two weeks before tumor formation. Abnormality of the innate IL-10+ IL-17+ gamma delta T cell expansion was demonstrated to be associated with the prevention of systemic circulation and the apoptosis induction of CD107a+ CD8+ mature CTLs and CD4+ Foxp3+ Treg cells in lymph nodes.