Stress states and psychobiological stress respones: Experimental-field study

压力和应对的现代交易理论指出，心理生物学压力反应是通过需求之间的不平衡出现的（即，压力源）和心理社会应对资源。本研究采用实验场范式探讨了急性和/或慢性应激情境下应激反应、认知、情绪和绩效之间的关系。1.采用气相色谱-质谱法测定了正常志愿者唾液中游离3-甲氧基-4-羟基苯乙二醇（MHPG）的含量，并以此作为焦虑、情绪和感知应激水平的测量指标。男性患者唾液游离MHPG水平与紧张焦虑、抑郁及应激症状评分显著相关，女性患者唾液游离MHPG水平与紧张焦虑、抑郁及应激症状评分无显著相关性。2.对门诊焦虑症患者在阿普唑仑、坦度螺酮等抗焦虑药物治疗1周前后进行唾液游离MHPG水平测定，并采用汉密尔顿焦虑量表进行焦虑评分。结果提示，唾液游离MHPG水平不仅可作为焦虑患者压力感知水平的评估指标，而且可作为焦虑患者对药物治疗反应的评估指标。

The modern transactional theories of stress and coping address that psychobiological stress responses emerge through an imbalance between demands (i.e., stressors) and psychosocial coping resources. This study is to examine the relationship among stress responsiveness, cognition, emotion and performance under acute and/or chronic stressful situations using the experimental-field paradigm.1.As a measure of the levels of anxiety, mood, perceived stress in normal volunteers, we determined the saliva level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG), using gas chromatography-mass spectrometry. The saliva level of free-MHPG was significantly correlated with score of tension-anxiety, depression and symptoms of stress in male, but not in female.2.We measured free MHPG levels in the saliva and scored the levels of anxiety with Hamilton Anxiety Scale in anxious outpatients, before and after drug treatment with anxiolytic drugs such as alprazolam and tandospirone for 1 week. The saliva level of free-MHPG was significantly reduced by alppazolam treatment.These findings suggest that the free Saliva MHPG level may be a useful indicators for assessing not only the level of perceived stress, but also the response to drug treatment for anxiety in anxious patients.