Stress states and psychobiological stress respones: Experimental-field study

压力状态和心理生物学压力反应：实验现场研究

• 批准号: 10410027
• 负责人: TSUDA Akira
• 金额: $ 5.89万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10410027/
• 关键词: Psychobiological stress response; perceived stress; saliva level of free 3-methoxy-4-hydroxyphenyleglycol(MHPG); anxiety disorder; anxiolytic drug; experimental-field study; mood; anxiety; メンタルストレステスト; 心臓血管系反応; 精神神経免疫反応; 日常生活ストレス; 性格特性; 健康行動

The modern transactional theories of stress and coping address that psychobiological stress responses emerge through an imbalance between demands (i.e., stressors) and psychosocial coping resources. This study is to examine the relationship among stress responsiveness, cognition, emotion and performance under acute and/or chronic stressful situations using the experimental-field paradigm.1.As a measure of the levels of anxiety, mood, perceived stress in normal volunteers, we determined the saliva level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG), using gas chromatography-mass spectrometry. The saliva level of free-MHPG was significantly correlated with score of tension-anxiety, depression and symptoms of stress in male, but not in female.2.We measured free MHPG levels in the saliva and scored the levels of anxiety with Hamilton Anxiety Scale in anxious outpatients, before and after drug treatment with anxiolytic drugs such as alprazolam and tandospirone for 1 week. The saliva level of free-MHPG was significantly reduced by alppazolam treatment.These findings suggest that the free Saliva MHPG level may be a useful indicators for assessing not only the level of perceived stress, but also the response to drug treatment for anxiety in anxious patients.

现代压力和应对的交易理论指出，心理生物应激反应是通过需求(即应激源)和心理社会应对资源之间的不平衡而产生的。本研究采用实验场范式，考察了急性和/或慢性应激条件下的应激反应、认知、情绪和表现之间的关系。1.采用气相色谱-质谱法，测定了健康志愿者唾液中游离的3-甲氧基-4-羟基苯乙二醇(MHPG)水平，以此来衡量正常志愿者的焦虑、情绪和感知压力水平。男性患者唾液中游离MHPG水平与紧张性焦虑、抑郁、应激症状显著相关，而女性则无相关性。2.对门诊焦虑患者在阿普唑仑、坦度螺酮等抗焦虑药物治疗1周前后，测定唾液中游离MHPG水平，并用汉密尔顿焦虑量表进行焦虑水平评分。阿尔帕唑仑治疗后患者唾液中游离MHPG水平显著降低，提示唾液中游离MHPG水平不仅可作为评估焦虑患者感受到的压力水平的有用指标，也可作为评估焦虑患者对药物治疗的反应的有用指标。

项目成果

津田彰,津田茂子: "行動医学への展開"ヘルスカウンセリング. 2. 66-73 (2000)

Akira Tsuda、Shigeko Tsuda：“行为医学的发展”健康咨询 2. 66-73 (2000)。

Yamada,S.et al.: "Dopamine D3 receptors modulate evoked dopamine release from slices of rat nucleus accumbens via muscarinic receptors,but not from the striatum."The Journal of Pharmacology and Experimental Therapeutics. 291. 994-998 (1999)

Yamada, S.等人：“多巴胺 D3 受体通过毒蕈碱受体调节大鼠伏隔核切片诱发的多巴胺释放，但不调节纹状体的多巴胺释放。”《药理学与实验治疗学杂志》。

西川 正ほか: "外来精神分裂病者におけるhaloperidol decanoateの使用状況" 精神治療学. 13. 1019-1024 (1998)

Tadashi Nishikawa 等人：“精神分裂症门诊患者的氟哌啶醇癸酸酯的使用状况”《心理治疗学》13. 1019-1024 (1998)。

津田彰 ら: "日本と英国の大学生における健康行動と健康知識"健康支援. (印刷中).

Akira Tsuda 等人：“日本和英国大学生的健康行为和健康知识”健康支持（正在出版）。

Yamada,S.et al.: "Dopamine autoreceptor in rat nucleus accumbens modulate prepulse inhibition of acoustic startle." Pharmacology Biochemistry & Behavior. 60. 803-808 (1998)

Yamada,S.et al.：“大鼠伏隔核中的多巴胺自身受体调节声惊吓的前脉冲抑制。”