权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Combined evaluation of lymph node metastasis in squamous cell carcinoma of the oral cavity

口腔鳞状细胞癌淋巴结转移的综合评价

基本信息

批准号：
10470439
负责人：
HIRATSUKA Hiroyoshi
金额：
$ 7.17万
依托单位：
UNIVERSITY OF THE RYUKYUS, SCHOOL OF MEDICINE
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

Aberrant expression of E-cadherin and/or catenins has been associated with invasiveness and metastasis in a variety of cancer types. However, tissue distribution of presrve or reduce of E-cadherin and catenins expression are unclear. Its clinical significance, moreover, has not been investigated in squamous cell carcinoma (SCC) of the tongue. Membranous expression of E-cadherin and catenins at superficial to middle part and peripheral invading front of the tumor were evaluated in formalin fixed, paraffin embedded biopsied specimens from a series of 79 SCC of the tongue by immunohistochemical methods using monoclonal antibodies. E-cadherin and α-, β-, and γ-catenins membranous expression were more preserved in superficial to middle part of the tumor than those of peripheral invading front (P=0.0007, =0.0001, <0.0001, and<0.0001, respectively). Univariate analysis revealed that membranous expression of E-cadherin, β-catenin, and γ-catenin at the invading front of the tumor showed siginif … More icantly reverse correlation with the T stage (P=0.02, =0.02, and =0.03, respectively), and reduced membranous expression of E-cadherin and γ-catenin was correlated with the TNM stage (P=0.01 and =0.04, respectively). In addition, reduced membarnous expression of E-cadherin and α-catenin, β-catenin, and γ-catenin also correlated significantly with the grade of carcinoma invasion (P=0.008, =0.01, =0.02, and =0.02, respectively) and pathologically proven lymph node metastasis (P<0.0001, =0.007, =0.02, and =0.001, respectively). Multivariate logistic regression models demonstrated that the combined evaluation of reduction or loss of E-cadherin and/or γ-catenin membranous expression was the independent predictor of cervical lymph node metastasis (relative risk ; 13.5). These results indicated that the assessment of E-cadherin and γ-catenin membranous expression at the peripheral invading front of the tumor is clinically useful, especially for selecting patients who required early neck treatment in SCC of the tongue. Less

E-钙粘蛋白和/或连环蛋白的异常表达与多种癌症类型的侵袭和转移有关。然而，E-cadherin和catenins表达的组织分布尚不清楚。其临床意义，而且，还没有研究在鳞状细胞癌（SCC）的舌头。采用单克隆抗体免疫组化方法检测79例舌鳞癌组织中上皮钙粘蛋白（E-cadherin）和连环蛋白（catenins）在舌鳞癌中、浅部及周边浸润面的表达。E-cadherin、α-catenins、β-catenins和γ-catenins在肿瘤中、浅部的表达较周围浸润前沿的表达更稳定（P分别为0.0007、0.0001、<0.0001）。单因素分析显示，E-钙粘蛋白、β-连环蛋白和γ-连环蛋白在肿瘤浸润前沿的膜表达与肿瘤浸润深度呈显著正相关。 ...更多信息 E-cadherin和γ-catenin的表达与TNM分期呈负相关（分别为P=0.02、P =0.02和P =0.03），E-cadherin和γ-catenin的表达与TNM分期呈负相关（分别为P=0.01和P =0.04）。此外，E-cadherin、α-catenin、β-catenin和γ-catenin的膜表达降低与胃癌浸润程度（P分别为0.008、0.01、0.02和0.02）和淋巴结转移（P分别为<0.0001、0.007、0.02和0.001）相关。多因素Logistic回归模型显示，E-cadherin和/或γ-catenin膜表达减少或缺失是颈淋巴结转移的独立预测因子（相对危险度; 13.5）。这些结果表明，E-cadherin和γ-catenin在肿瘤周围浸润前沿的膜表达的评估在临床上是有用的，特别是对于选择需要早期颈部治疗的舌鳞癌患者。少