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Mechanisms for the central and peripheral regulation of food and water intake in the neonatal chick

新生雏鸡食物和水摄入的中枢和外周调节机制

基本信息

批准号：
11460124
负责人：
FURUSE Mitsuhiro
金额：
$ 9.79万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

Leptin plays an important role in regulation of food intake and metabolism in rats and mice. However, central administration of leptin did not alter food intake of chicks. Feeding behavior was stimulated by low levels of norepinephrine and decreased by further production of norepinephrine in chicks. Central GLP-1 suppressed food intake and induced sleeping behavior. Sleeping behavior was also induced by central morphine and consequently food intake was suppressed. Relationships between GLP-1 and morphine in the brain were studied, but no interaction was detected. GLP-1 inhibited water intake as well as food intake. It was suggested that N-terminal histidine had a key role for the action of GLP-1. Central gastrin as a brain-gut peptide inhibited both food intake and food passage from the crop. CCK, having a similar amino acid sequence for gastrin, suppressed food intake and the effect was stronger in a large size molecule than in a small one. Central histamine, a-MSH and bombesin strongly inhibited food intake. In mammalian species, orexin, MCH, galanin and motilin have been recognized as an orexigenic factors. However, these peptides did not enhance food intake of chicks. Peripheral administration of erythromycin, having an action like motilin, did not show any effects for feeding. Orexigenic actions of both NPY and norepinephrine were depressed by the inhibition of nitric oxide synthesis in the brain. Release of arginine vasotocin inhibited by opioid peptide. Synthesis and release of arginine vasotocin was simultaneously decreased under a hypertonic condition.

瘦素在调节大鼠和小鼠的食物摄取和代谢中起重要作用。然而，瘦素的中央管理并没有改变雏鸡的摄食量。低水平的去甲肾上腺素刺激雏鸡的摄食行为，而进一步产生去甲肾上腺素则使其摄食行为下降。中枢GLP-1抑制食物摄入并诱导睡眠行为。睡眠行为也被中枢吗啡诱导，从而抑制摄食。研究了脑中GLP-1和吗啡之间的关系，但未检测到相互作用。GLP-1抑制水摄入以及食物摄入。这表明N-末端组氨酸对GLP-1的作用具有关键作用。中枢胃泌素作为一种脑肠肽，既能抑制作物的摄食，又能抑制作物的食物通道。CCK具有与胃泌素相似的氨基酸序列，抑制摄食，并且在大分子中的作用比小分子中的作用更强。中枢组胺、α-MSH和蛙皮素强烈抑制摄食。在哺乳动物中，食欲素、MCH、甘丙肽和胃动素被认为是促食欲因子。然而，这些肽并没有提高雏鸡的摄食量。红霉素具有类似胃动素的作用，外周给药对摄食无任何影响。通过抑制脑中一氧化氮的合成，可抑制NPY和去甲肾上腺素的促食欲作用。阿片肽抑制精氨酸催产素的释放。在高渗条件下，精氨酸催产素的合成和释放同时减少。