Studies on the functional amino acid nutrition and ist application

l-色氨酸代谢物Kynurenic acid （KYNA）通过同时抑制α 7烟碱乙酰胆碱（α 7nACh）受体和n -甲基- d -天冬氨酸（NMDA）受体亚群NR2A和NR2B，诱导应激下的强镇静作用。l -天冬氨酸（L-Asp）和d -天冬氨酸（D-Asp）也能减弱应激反应。L-Asp可以通过NMDA受体诱导应激行为的镇静和催眠作用，而D-Asp可能通过NMDA受体以外的其他受体同时参与。急性和慢性l -丝氨酸治疗对抗抑郁样状态指数的影响不同。急性l -丝氨酸治疗增加脑内l -丝氨酸，慢性l -丝氨酸治疗增加脑内d -丝氨酸。过度活跃的动物大脑中l -酪氨酸向d -酪氨酸的转化可能更高，这可能导致多巴胺浓度低。此外，被称为镇静因子的l -丝氨酸在过度活跃的动物中含量较低。

Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor.Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.