Studies on the functional amino acid nutrition and ist application

L色氨酸代谢产物犬尿酸通过同时抑制α7烟碱型乙酰胆碱(α7nACh)受体和N-甲基-D-天冬氨酸(N-甲基-D-天冬氨酸)受体亚基NR2A和NR2B亚基，在应激状态下产生强烈的镇静作用。L-天冬氨酸(L-天冬氨酸)和D-天冬氨酸(D-天冬氨酸)也可以减弱应激反应。L-天冬氨酸可通过N-甲基-D-天冬氨酸受体对应激行为产生镇静催眠作用，而D-天冬氨酸可能通过N-甲基-D-天冬氨酸受体以外的其他受体同时参与。L-丝氨酸的急性和慢性治疗对抗抑郁药样状态的一个指数有不同的影响。急性L丝氨酸升高，L丝氨酸升高，L丝氨酸慢性治疗使脑内D丝氨酸升高。多动动物脑内L酪氨酸向D酪氨酸的转化率可能较高，这可能是多巴胺浓度降低的原因。此外，被称为镇静因子的L-丝氨酸在多动动物中含量较低。

Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor.Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.