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Mechanisms for feeding and sleeping behavior in the neonatal chick

新生雏鸡进食和睡眠行为的机制

基本信息

批准号：
13460118
负责人：
FURUSE Mitsuhiro
金额：
$ 8.77万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13460118/
关键词：
CRF GLP-1 NPY Ghrelin L-pipecolic acid Food intake Sleep Chick CRF α-MSH GRF Ghrelin Ketone body AGRP Catecholamine Chick

项目摘要

Corticotropin-releasing factor (CRF), urocortin and urotensin I share amino acid sequences, and they inhibit food intake in mammals. The effect of these three peptides on food intake in the neonatal chick was compared. The results indicated that the suppressive effect on food intake was strongest for CRF followed by urotensin I, then urocortin. Both CRF and glucagon-like peptide-1 (GLP-1) inhibit food intake of chicks, but they also produce other behaviors. In conclusion, CRF and GLP-1 interact in the chick brain, but the response depends on the behavior being measured. The involvement of endogenous glucagon-like peptide-1 (GLP-1) on feeding in chicks was examined. Endogenous GLP-1 may be important in the regulation of feeding in layer-type chicks but not in broiler chicks. Neuropeptide Y (NPY) is one of the most potent neuropeptides known to induce feeding in animals, and has been suggested to be a physiological signal for food intake. It was elucidated that NPY receptor agonists, except for neuropeptide Y-(13-36), are potent stimulators of food intake in the neonatal chick. Ghrelin is an endogenous ligand for the growth hormone (GH) secretagogue (GHS) receptor. The effect of central injection of different ghrelins including chicken and bullfrog ghrelin, and synthetic GH-releasing peptide (GHRP) on feeding of neonatal chicks was investigated. The results indicate that the chicken GHS receptor is affected by several forms of GHS, and that food intake of neonatal chicks is inhibited by GHS receptor agonists. L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the brain. The results suggest that L-PA has an important role for the regulation of feeding and sleeping behaviors in the neonatal chick.

促肾上腺皮质激素释放因子（CRF）、尿皮质素和尾加压素I共享氨基酸序列，并且它们抑制哺乳动物的食物摄取。比较了这三种肽对新生雏鸡摄食量的影响。结果表明，CRF对摄食的抑制作用最强，其次是尾加压素I，然后是尿皮质素。CRF和胰高血糖素样肽-1（GLP-1）都抑制雏鸡的摄食，但它们也产生其他行为。总之，CRF和GLP-1在鸡脑中相互作用，但反应取决于被测量的行为。研究了内源性胰高血糖素样肽-1（GLP-1）对雏鸡摄食的影响。内源性GLP-1可能是重要的，在蛋鸡型鸡，但不是在肉鸡的喂养调节。神经肽Y（neuropeptide Y，NPY）是目前已知的诱导动物摄食的最强神经肽之一，被认为是动物摄食的生理信号。结果表明，除神经肽Y-（13-36）外，其他神经肽Y受体激动剂均能有效地刺激雏鸡摄食。Ghrelin是生长激素（GH）促分泌素（GHS）受体的内源性配体。研究了中枢注射鸡和牛蛙生长激素释放肽（Ghrelin）及合成生长激素释放肽（GHRP）对雏鸡生长的影响。结果表明，鸡GHS受体受几种形式的GHS的影响，GHS受体激动剂抑制新生鸡的摄食。L-哌啶酸（L-PA）是L-赖氨酸（L-Lys）在脑中的主要代谢中间体。结果表明，L-PA对新生雏鸡的摄食和睡眠行为具有重要的调节作用。