Studies on regulation of energy metabolism via central nervous system in neonatal chicks

中枢神经系统调节新生雏鸡能量代谢的研究

• 批准号: 16380191
• 负责人: FURUSE Mitsuhiro
• 金额: $ 10.18万
• 依托单位: KYUSHU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380191/
• 关键词: thyrotropin-releasing hormone; thyroxine; triiodothyronine; rectal temperature; heat production; chick; brain; corticotropin-releasing factor; 甲状腺刺激ホルモン放出ホルモン

To understand thermal regulation of neonatal chicks, the contribution of thyrotropin-releasing hormone (TRH), a key regulator of the hypothalamus-pituitary-thyroid axis, was investigated. Intracerebroventricular (i.c.v.) injection of TRH increased body temperature, but did not change plasma triiodothyronine (T_3) and thyroxine (T_4) concentrations. Intraperitoneal (i.p.) injection of T_3 and T_4 did not influence body temperature. Thereafter, the relationships between TRH and the hypothalamus-pituitary-adrenal axis and sympathetic nervous system were further investigated. Central TRH stimulated both corticosterone and epinephrine release. The i.c.v. injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T_3 and T_4 concentrations. The i.p. injection of epinephrine did not induce hyperthermia. Therefore, the thermoregulatory response to TRH may differ in neonatal stages being dependent upon the stimulation of the hypothalamus-pituitary-adrenal axis rather than the hypothalamus-pituitary-thyroid axis. Heat production during embryonic stages were influenced by genetic selection. On the other hand, nutrients influencing chick behaviors were found out. Carnosine inhibited food intake and iduced hyperactiveity. The constituents of carnosine, β-alanine (β-Ala) and L-histidine (His), also inhibited food intake, whereas β-Ala plus His induced hypoactivity manifested as sleep-like behavior. Central creatine, phosphatidylserine, L-serine and (-)-epigallocatechin gallate reduced the stress responses in chicks.

为了了解新生雏鸡的热调节，我们研究了促甲状腺素释放激素（TRH）的作用，TRH 是下丘脑-垂体-甲状腺轴的关键调节剂。脑室内 (i.c.v.) 注射 TRH 会升高体温，但不会改变血浆三碘甲状腺原氨酸 (T_3) 和甲状腺素 (T_4) 浓度。腹膜内（i.p.）注射T_3和T_4不影响体温。此后，进一步研究TRH与下丘脑-垂体-肾上腺轴和交感神经系统的关系。中枢 TRH 刺激皮质酮和肾上腺素的释放。 i.c.v.注射促肾上腺皮质激素释放因子受体拮抗剂减弱了TRH引起的体温和皮质酮浓度的变化，但不影响血浆T_3和T_4浓度。 ip。注射肾上腺素不会引起高热。因此，新生儿阶段对TRH的体温调节反应可能有所不同，这取决于下丘脑-垂体-肾上腺轴而不是下丘脑-垂体-甲状腺轴的刺激。胚胎阶段的产热受到遗传选择的影响。另一方面，发现了影响雏鸡行为的营养物质。肌肽抑制食物摄入并引起多动症。肌肽、β-丙氨酸 (β-Ala) 和 L-组氨酸 (His) 的成分也会抑制食物摄入，而 β-Ala 加 His 引起的活动减退表现为睡眠样行为。中枢肌酸、磷脂酰丝氨酸、L-丝氨酸和 (-)-表没食子儿茶素没食子酸酯可降低雏鸡的应激反应。

项目成果

Oral administration of β-alanine carnosine concentratios in the muscles and brains of chickens

口服β-丙氨酸肌肽集中在鸡的肌肉和大脑中

• 发表时间: 2005
• 期刊: Animal Science Journal 76(3)
• 作者: Tomonaga;S. et al.
• 通讯作者: S. et al.

Gonadotropin-inhibiting hormone stimulates feeding behavior in chicks

• DOI: 10.1016/j.brainres.2005.05.035
• 发表时间: 2005-07-19
• 期刊: BRAIN RESEARCH
• 影响因子: 2.9
• 作者: Tachibana, T;Sato, M;Furuse, M
• 通讯作者: Furuse, M

The hypothalamus is involved in the anorexic effect of glucagon-like peptide-1 in chicks.

• DOI: 10.1016/j.cbpb.2003.09.026
• 发表时间: 2004
• 期刊: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
• 作者: T. Tachibana;Keiko Hirofuji;Mako Matsumoto;M. Furuse;S. Hasegawa;F. Yoshizawa;K. Sugahara

Effect of central administration of canosine and its constituents on behavior in chicks

犬碱及其成分的中枢给药对雏鸡行为的影响

• 发表时间: 2004
• 期刊: Brain Research Bulletin 63(1)
• 作者: Tomonaga;S. et al.
• 通讯作者: S. et al.

Effect of central administration of prolactin-releasing peptide on feeding in chicks.

催乳素释放肽中枢给药对雏鸡采食的影响。

• 发表时间: 2004
• 期刊: Physiology & Behavior 80(5)
• 作者: Tachibana;T.;Saito;S.;Tomonaga;S.;Takagi;T.;Saito;E.-S.;Nakanishi;T.;Koutoku;T.;Tsukada;A.;Ohkubo;T.;Boswell;T.;Furuse;M.
• 通讯作者: M.