Light-nutritional treatment for circadian disruption using functional nutrition

在现代世界，不规则的光照破坏了生物钟，导致了许多疾病，包括睡眠障碍、肥胖、糖尿病、高血压和癌症。确定能够调节生物钟特性的营养因素是很重要的。本研究确定了可以调节大脑和外周器官中生物钟基因的活动节奏或表达的功能性氨基酸。本研究通过动物模型进一步证实了这些氨基酸对时钟相关疾病的效用。这些数据强调了氨基酸营养对调节昼夜节律中断的重要性。

Disruption of the circadian clock by irregular illumination in the modern world causes many diseases, including sleep disorders, obesity, diabetes, hypertension, and cancer. It is important to identify the nutritional factors that can modulate the properties of the circadian clock. This study identified the functional amino acids that can modulate the activity rhythm or expression of clock genes in the brain and peripheral organs. This study further confirmed the utility of these amino acids for clock-related diseases using animal models. These data highlight the importance of amino acid nutrition for the regulation of the circadian disruption.