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The control of gastrointestinal motility in the chichen by the nutrients

营养物质对鸡胃肠蠕动的控制

基本信息

批准号：
06660352
负责人：
FURUSE Mitsuhiro
金额：
$ 1.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

The mechanism by which medium chain triacylglycerol (MCT) delayd the crop emptying rate in the chicken was investigated. The effect of administration route of MCT was determined. After oral or intraperitoneal administration of saline, MCT or long chain triacylglycerol (LCT), the crop emptying rate was measured. Only oral administration of MCT delayd the crop emptying compared with other treatments. The influence of alkaline treatment on the delayd crop emptying induced by MCT was investigated to clarify the involvement of acidity. The alkaline treatment did not improve the crop emptying and the highest treatment of alkaline further delayd the crop emptying rate. The involvement of dopaminergic or sympathetic neuron was invesetigated. The involvement of dopaminergic action was negligible, but the block of sympathetic neuron further delayd the crop emptying. The role of cholinergic mechanisms was investigated. Vagotomy altered the crop emptying of chicks given LCT,but did not alter it in chicks given MCT.Denervation in the cranial rete and lateral commisure of the gizzard further inhibited the food passage induced by MCT.Administration of cisapride, which induces acetylcholine release from the myenteric nerves, and atropine, a muscarinic cholinergic antagonist, both delayd crop emptying of chicks given medium chain triacylglycerol. These results demonstrate that cholinergic factors are not involved in the delayd forward movement of the food containing MCT from the crop of chicks. The effect of sodium nitroprusside (SNP), a spontaneous nitric oxide releaser, on the forward passage of the crop contents of chicks receiving MCT was studied. Crop emptying rate was significantly delayd as dietary SNP increased.

本文研究了中链甘油三酯（MCT）延缓鸡胃排空的机理。确定MCT给药途径的影响。经口或腹膜内给予生理盐水、MCT或长链三酰甘油（LCT）后，测量作物排空率。与其他处理相比，仅口服MCT延迟了作物排空。研究了碱处理对MCT诱导的延迟作物排空的影响，以阐明酸度的参与。碱处理不能提高作物的排空速率，高碱处理进一步延缓了作物的排空速率。探讨多巴胺能或交感神经元的受累情况。多巴胺能神经元的作用可以忽略不计，但交感神经元的阻滞可进一步延迟作物排空。研究了胆碱能机制的作用。迷走神经切断术改变了给予LCT的小鸡的作物排空，但没有改变它在给予MCT的小鸡中。在颅网和外侧连合的肌胃去神经进一步抑制由MCT诱导的食物通道。西沙必利，诱导乙酰胆碱从肌间神经释放，和阿托品，毒蕈碱胆碱能拮抗剂，都延迟了给予中链三酰甘油的小鸡的作物排空。这些结果表明，胆碱能因子不参与含MCT的食物从鸡群中延迟向前移动。研究了硝普钠（SNP）（一种自发性一氧化氮释放剂）对接受MCT的雏鸡的作物内容物向前传递的影响。随着日粮SNP含量的增加，作物排空速率显著延迟。