Unravelling the immunology of complex glycolipids by chemical synthesis

通过化学合成揭示复杂糖脂的免疫学

• 批准号: DP160100597
• 负责人: Prof Spencer Williams
• 金额: $ 44.62万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160100597
• 关键词: Unravelling; immunology; complex; glycolipids; chemical

This project seeks to develop new approaches to chemically synthesise bacterial and fungal glycolipids and develop a molecular-level understanding of their effect on the immune system. Bacterial and fungal glycolipids are exotic chemical species that act as danger signals to prime and modulate our innate immune responses. These complex glycolipids possess powerful immunological activities that continue to shape our understanding of innate immunity, yet cannot be acquired from natural sources in the quantities and purity needed. The approaches expected to be developed in the project will be used to illuminate molecular details of immune signalling through pattern recognition receptors and presentation on specialised glycolipid antigen-presenting molecules. Outcomes may include new ways to fight disease and promote health by marshalling the resources of the immune system.

该项目旨在开发化学合成细菌和真菌糖脂的新方法，并从分子水平了解它们对免疫系统的影响。细菌和真菌糖脂是外来的化学物质，它们作为危险信号启动和调节我们的先天免疫反应。这些复杂的糖脂具有强大的免疫活性，继续塑造我们对先天免疫的理解，但不能从自然来源获得所需的数量和纯度。预计将在该项目中开发的方法将用于通过模式识别受体和特殊糖脂抗原呈递分子的呈现来阐明免疫信号的分子细节。结果可能包括通过整合免疫系统资源来抗击疾病和促进健康的新方法。