Chemical tools for the study of mycobacterial glycolipid biosynthesis

用于研究分枝杆菌糖脂生物合成的化学工具

• 批准号: DP0449626
• 负责人: Prof Spencer Williams
• 金额: $ 21.94万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-14 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0449626
• 关键词: Chemical; tools; study; mycobacterial; glycolipid

Mycobacteria are responsible for human morbidity and mortality on a immense scale. The cell wall structure of these bacteria is extremely complex and offers many novel therapeutic opportunities. In this proposal we will use a synergetic interplay of chemistry, biochemistry and microbiology to study the biosynthesis of essential cell wall molecules conserved across all mycobacteria, the phosphatidylinositol mannosides. Substrates and inhibitors will be prepared and studied using novel biochemical and microbiological methods. This project will enhance our understanding of cell wall synthesis in mycobacteria and will lay the ground work for the discovery of novel antibiotics.

分枝杆菌在很大程度上导致了人类的发病率和死亡率。这些细菌的细胞壁结构极其复杂，提供了许多新的治疗机会。在这项提议中，我们将使用化学、生物化学和微生物学的协同作用来研究所有分枝杆菌中保守的基本细胞壁分子的生物合成，磷脂酰肌醇甘露糖苷。将使用新的生化和微生物方法制备和研究底物和抑制剂。该项目将加深我们对分枝杆菌细胞壁合成的了解，并将为发现新的抗生素奠定基础。