Control of immune recognition and response by microbial metabolites

微生物代谢物对免疫识别和反应的控制

• 批准号: DP210100235
• 负责人: Prof Spencer Williams
• 金额: $ 31.28万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP210100235
• 关键词: Control; immune; recognition; response; microbial

This project aims to study immune recognition of microbial metabolites and develop reagents to control immune responses. Chemical synthesis will be used to develop new antigens for unconventional T cells and the first soluble agonists and antagonists of a glycolipid-sensing immune receptor. Expected outcomes include the discovery of new immune effectors, broadening our knowledge of the repertoire of small molecules that can be sensed by the immune system, and developing chemical approaches to promote or dampen immune responses. Major benefits include research training in chemical biology, strengthened international linkages and fundamental insights into the chemical basis of immune recognition and response.

本项目旨在研究微生物代谢产物的免疫识别，并开发控制免疫反应的试剂。化学合成将用于开发非常规T细胞的新抗原和糖脂敏感免疫受体的第一种可溶性激动剂和拮抗剂。预期成果包括发现新的免疫效应物，扩大我们对免疫系统可以感知的小分子库的了解，以及开发促进或抑制免疫反应的化学方法。主要的好处包括化学生物学的研究培训，加强国际联系和对免疫识别和反应的化学基础的基本见解。