Mannose metabolism in pathogenic microorganisms
Mannose metabolism in pathogenic microorganisms
批准号:
DP0770839
负责人:
Prof Spencer Williams
金额:
$17.34万
依托单位国家:
澳大利亚
项目类别:
Discovery Projects
财政年份:
2008
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2008-01-01 至 2010-12-31
中文摘要
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英文摘要
Current treatments for tuberculosis and leishmaniasis are failing due to chronic underinvestment by the private sector and public agencies over many decades. The causative agents, the microorganisms Leishmania spp and Mycobacterium tuberculosis, respectively, use sugar processing pathways that differ from humans, and thus represent targets for new drugs. We will study two related sugar-processing biochemical pathways in these organisms. We will develop new ways to measure enzyme activity using mass spectrometry, and new reagents to clone several biosynthetic enzymes. Our work will lay a foundation for new antibiotics to combat these insidious diseases, and will foster Australian expertise in chemical biology and innovative basic science.
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依托单位:
国内基金
海外基金
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