Dissecting catalysis and inhibition of a unique endo-acting mannose-processing glycosidase

剖析独特的内作用甘露糖加工糖苷酶的催化和抑制

• 批准号: DP120101396
• 负责人: Prof Spencer Williams
• 金额: $ 25.83万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120101396
• 关键词: Dissecting; catalysis; inhibition; unique; endo

Defects in the attachment of carbohydrates to proteins are a hallmark of diseases such as cancer and viral infection. This project will dissect the molecular details of the bond-making and breaking steps that occur during the synthesis of glycoproteins assisting in the development of innovative new drugs.

碳水化合物与蛋白质的结合缺陷是癌症和病毒感染等疾病的标志。该项目将剖析糖蛋白合成过程中发生的成键和断裂步骤的分子细节，有助于创新新药的开发。