Dissecting catalysis and inhibition of a unique endo-acting mannose-processing glycosidase

剖析独特的内作用甘露糖加工糖苷酶的催化和抑制

• 批准号: DP120101396
• 负责人: Prof Spencer Williams
• 金额: $ 25.83万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP120101396
• 关键词: Dissecting; catalysis; inhibition; unique; endo

Defects in the attachment of carbohydrates to proteins are a hallmark of diseases such as cancer and viral infection. This project will dissect the molecular details of the bond-making and breaking steps that occur during the synthesis of glycoproteins assisting in the development of innovative new drugs.

碳水化合物附着在蛋白质上的缺陷是癌症和病毒感染等疾病的标志。该项目将剖析糖蛋白合成过程中发生的键形成和断裂步骤的分子细节，以帮助开发创新的新药。