Survery and evaluation of anti-malaria plant in Indenesia

印度尼西亚抗疟疾植物调查与评价

• 批准号: 13574013
• 负责人: YOSHIHARA Teruhiko
• 金额: $ 7.81万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13574013/
• 关键词: Indonesea; Kalimantan; Sumatera; malaria; anti-malarial plant; Babesia gibsoni

The first survey : Aug 3, 〜Aug 7, 2001 Survey was done at the place near Palangkaraya in Central Kalimantan. Twenty seven anti-malaria plants were collected. The determination of species was done by the researchers of LIPI.The second survey : Dec 14, 〜Dec 23, 2002 Survey was done at the place near Palembang and Lampung in South Sumatera. Eveven plants were collected.Anti Babesia compounds were isolated from the plants according to the bioassay of Babesia gibsoni. Phyllanthus niruri : Pentahydroxyxanthon, Ellagic acid glucopyranoside, Arcangelisia flava : Berberine, 20-Hydroxy ecdisone Peronema canescens : Peronemin A3, Quercetin glucopyranoside Garcinia celebica : Catechine, Catechine dimer Shorea balangeran : Vaticanol A, B, G Garacinia rigida : Mangostin Curcuma zedoaria : Zedoalactone B, C Cinnamomum sintoc : 1-allyl-3,4-dimethyl benzene, 1-allyl-3,5-dimethoxy phenol, euqenol, innamaldehyde, cinnamic acid, cinnamyl alcohol, 3-(4-hydroxy-3-methoxy phenyl)-propenal, vanillin, sitosterol, 2,3-Bis-(4-hydroxy-3-methoxy-benzyl)-butane-1,4-diol)Berberin from A-flava and mangostin from G-rigida showed the high anti-malaria adtizities. These two plants are effutive, as medical plants.

第一次调查：2001年8月3日8月7日调查在加里曼丹中部的帕朗卡拉亚附近进行。收集了27种抗疟疾植物。第二次调查：2002年12月14日至12月23日，在南苏门答腊岛的帕伦邦和楠榜附近进行。收集了10株植物，通过对吉氏巴氏巴氏虫的生物测定，从植物中分离出抗巴氏虫的化合物。叶下珠：五羟基黄药酮、鞣花酸吡喃葡萄糖苷、黄圆盖蕨：小檗碱、20-羟基蜕皮酮Peronema canescens：Peronemin A3、槲皮素吡喃葡萄糖苷藤黄：儿茶素、儿茶素二聚体Shorea balangeli：Vaticanol A、B、G Garacinia rigida：Mangostin姜黄：Zedoalactone B、C肉桂：1-烯丙基-3，4-二甲基苯、1-烯丙基-3，5-二甲氧基苯酚、丁香酚、肉桂醛、肉桂酸、肉桂醇、3-其中，（4-羟基-3-甲氧基苯基）丙烯醛、香草醛、谷甾醇、2，3-双（4-羟基-3-甲氧基苄基）丁二醇、小檗碱和芒果苷具有较强的抗疟活性。这两种植物作为药用植物都很活泼。