THE MECHANISM OF THE EXPRESSION OF TOLERANCE FOR ISCHEMIA BY ISCHEMIC PRECONDITIONING IN FETAL BRAIN.

胎脑缺血预处理表达缺血耐受的机制。

• 批准号: 12470349
• 负责人: ARAKI Tsutomu
• 金额: $ 8.19万
• 依托单位: NIPPON MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470349/
• 关键词: brain ischemia; brain hypoxia; fetus; ischemic preconditioning; adenosine; theophylline; ischemic tolerance; 5'-nucleotidase; Brain; Adenosine; 5'-nucleotidase

[PURPOSE] The purpose of this study is to examine the relationship between ischemic preconditioning and ischemic tolerance in fetal brain, and evaluated the mechanism of the expression of the tolerance for ischemia by ischemic preconditioning.[METHOD] We performed ischemic preconditioning by repeated umbilical cord occlusion, and then inducted fetal brain ischemia and hypoxia by repeated umbilical cord occlusion in ten chronically instrumented fetal sheep with and without adenosine agonists and antagonists.[RESULTS] Fetal brain tolerance for ischemia was enhanced by ischemic preconditioning, which was partially augmented by adenosine agonists and diminished by adenosine antagonists.[CONCLUSION] Ischemic preconditioning elicits fetal brain tolerance for ischemia, which was at least in part regulated by adenosine.

[目的]探讨缺血预适应与胎脑缺血耐受的关系，探讨缺血预适应在胎脑对缺血耐受性的表达机制。[方法]采用反复脐带结扎的方法进行缺血预适应，再用腺苷激动剂和拮抗剂分别与不加用腺苷激动剂和拮抗剂诱导胎羊胎脑缺血缺氧。[结果]缺血预适应可提高胎脑对缺血的耐受性，腺苷激动剂可部分增强缺血耐受，腺苷拮抗剂可部分抑制缺血耐受。[结论]缺血预适应可诱导胎儿脑缺血耐受，这种耐受至少部分受腺苷调节。

项目成果

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Takeuchi 等人：“先兆子痫中血浆腺苷的体外血小板聚集调节”Gynecol Obstet Invest. 51·1 (2001)。

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Suzuki S.等：“单羊膜双胞胎妊娠中的宫内并发症的发生率”Acta Gynecol Obstet. 265・2 (2001)。

Yoneyama Y, et al: "Plasma adenosine levels and the expression of P-selectin on platelets in preeclampsia"Obstet Gynecol. 印刷中. (2001)

Yoneyama Y 等人：“先兆子痫中血小板上的血浆腺苷水平和 P-选择素的表达”Obstet Gynecol 出版（2001 年）。

Yamada T. et al.: "Effects of maternal oxygen supplementation on fetal oxygenation and lipid peroxidation in late gestation goat"J Nippon Med Sch. 70(in press). (2003)

Yamada T.等人：“母体供氧对妊娠晚期山羊胎儿氧合和脂质过氧化的影响”J Nippon Med Sch。