Research and Development of System for Continuous Measurement of Transient Response of Arterial Wall to Administration of Nitroglycerine

连续测量动脉壁对硝酸甘油给药的瞬态反应系统的研制

• 批准号: 12555113
• 负责人: KANAI Hiroshi
• 金额: $ 8.06万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12555113/
• 关键词: Arteriosclerosis; Medical Ultrasound; Elasticity of Arterial Wall; Phased tracking method; Noninvasive Measurement; Tissue Characterization; Nitroglycerine; Carotid artery; 弾性特性; アテローム; バイオレオロジー

We previously developed a new method, the phased tracking method, for accurately tracking the movement of the heart wall and arterial wall based on both the phase and magnitude of the demodulated ultrasonic signals to determine the instantaneous position of an object. With this method, the local change in wall thickness during one heartbeat can be determined. We have now developed a real-time system for continuously measuring the change in thickness of the arterial wall. In this system, four high-speed digital signal processing chips are employed for realizing the initially developed method in real time. The tracking results for both sides of the wall are superimposed on the M (motion)-mode image. The change in thickness of the arterial wall as small as several micrometers can be successfully detected in real time with good reproducibility. The elasticity of the arterial wall is derived from the blood pressure. In in vivo experiments, the rapid response of the change in wall thickness of the carotid artery to the administration of nitroglycerine (NTG) is evaluated for a young healthy subject and a young smoker. When the change in thickness is plotted against the simultaneously measured pressure, such curves also change due to the administration of NTG. This is shown every 35 seconds after the administration. This new real-time system offers potential for quantitative diagnosis of early-stage arteriosclerosis by evaluation of the rapid response of the cardiovascular system to NTG.

我们之前开发了一种新的方法，即相位跟踪法，用于根据解调超声信号的相位和幅度精确跟踪心脏壁和动脉壁的运动，以确定物体的瞬时位置。利用这种方法，可以确定一次心跳期间局部壁厚的变化。我们现在已经开发了一种实时系统，可以连续测量动脉壁厚度的变化。在该系统中，采用了4个高速数字信号处理芯片来实时实现初步开发的方法。将墙体两侧的跟踪结果叠加在M（运动）模式图像上。动脉壁厚度的变化小至几微米，可成功实时检测，重现性好。动脉壁的弹性来源于血压。在体内实验中，评估了年轻健康受试者和年轻吸烟者的颈动脉壁厚度变化对硝酸甘油（NTG）施用的快速反应。当厚度的变化与同时测量的压力相对应时，由于NTG的使用，这些曲线也会发生变化。在给药后每35秒显示一次。这种新的实时系统通过评估心血管系统对NTG的快速反应，为早期动脉硬化的定量诊断提供了潜力。

项目成果

M. Watanabe: "Investigation on accuracy in measurement of small change in arterial wall thickness by computer simulation of ultrasonic field in 3-D space"Journal of Acoustic Society of Japan. 58. 696-703 (2002)

M. Watanabe：“通过 3D 空间中超声场的计算机模拟测量动脉壁厚度微小变化的精度研究”日本声学学会杂志。

渡辺 優, 長谷川英之, 金井 浩: "3次元音場の模擬による動脈壁厚変化計測の精度検討"日本音響学会誌. 58. 696-703 (2002)

Yu Watanabe、Hideyuki Hasekawa、Hiroshi Kanai：“通过模拟三维声场来检查测量动脉壁厚度变化的准确性”日本声学学会杂志 58. 696-703 (2002)。

金井 浩, 他70名: "『臨床検査』臨時増刊号『超音波検査の技術と臨床』"医学書院. 335 (2001)

Hiroshi Kanai 等 70 人：《临床检查》特刊《超声检查技术与临床实践》Igaku Shoin 335 (2001)。

Y.Koiwa: "Left Ventricular Transmural Systolic Function by High-sensitivity Velocity Measurement "Phased Tracking Method" Across the Septum in Doxorubicin Cardiomyopathy"Ultrasound in Medicine and Biology. 28. 1395-1403 (2002)

Y.Koiwa：“通过高灵敏度速度测量“相控跟踪法”穿过多柔比星心肌病的隔膜来测量左心室透壁收缩功能”医学和生物学中的超声。

Y. Koiwa: "Systolic Heterogeneity of Transmural Myocardial Function in Normal Subjects: Physiological Function Heterogeneity"Tohoku J. Exp. Med. 197. 183-187 (2002)

Y. Koiwa：“正常受试者透壁心肌功能的收缩异质性：生理功能异质性”Tohoku J. Exp。