Research and Development of Medical Ultrasonic Equipment with Realtime Control of Ultrasonic Beam

超声束实时控制医用超声设备的研发

• 批准号: 10555134
• 负责人: KANAI Hiroshi
• 金额: $ 5.63万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10555134/
• 关键词: atherosclerosis; medical ultrasonics; elasticity; phased tracking; noninvasive measurement; tissue characterization; atheroma; bio-rheology; レオロジー

We have already developed a new method for accurately tracking the movement of the heart wall and arterial wall based on both the phase and magnitude of the demodulated signals to determine the instantaneous position of an object. In this research, a real-time system for measuring change in the thickness of the myocardium and the arterial wall is presented. In this system, an analytic signal from the standard ultrasonic diagnostic equipment is A/D converted at a sampling frequency of 1 MHz. By pipelining and parallel processing using four high-speed digital signal processing (DSP) chips, the above developed method is realized in real time. The tracking results for both sides of the heart/arterial wall are superimposed on the M (motion)-mode image in the work-station (WS) and the thickness changes of the heart/arterial wall are also displayed in real time. By this system, velocity signals, that is, the instantaneous movement of the heart/arterial wall with small amplitudes less than several micrometers on the motion resulting from a heartbeat with large amplitude of several millimeters, can be successfully detected in real time with sufficient reproducibility in the frequency range up 80Hz. From the regional change in thickness of the heart wall, spatial distribution of myocardial motility and contractility can be evaluated. For the arterial wall, its elasticity can be evaluated by referring to the blood pressure. In in vivo experiments, the rapid response of the change in wall thickness of the carotid artery to the dose of the nitroglycerine (NTG) is evaluated. This new real-time system offers potential for quantitative diagnosis of myocardial motility, early-stage atherosclerosis, and the transient evaluation of the rapid response of the cardiovascular system to physiological stress.

我们已经开发了一种新的方法，基于解调信号的相位和幅度来精确跟踪心壁和动脉壁的运动，以确定物体的瞬时位置。在这项研究中，提出了一种实时测量心肌和动脉壁厚度变化的系统。在该系统中，来自标准超声诊断设备的分析信号以1 MHz的采样频率进行A/D转换。通过4片高速数字信号处理芯片的流水线并行处理，实现了上述方法的实时实现。在工作站(WS)中，将心脏/动脉壁两侧的跟踪结果叠加在M(运动)模式图像上，并实时显示心脏/动脉壁厚度的变化。通过该系统，在80 Hz以上的频率范围内，可以成功地实时检测到速度信号，即在大幅度为几毫米的心跳引起的运动中，小幅度小于几微米的心脏/动脉壁的瞬时运动，并具有足够的重复性。从心壁厚度的区域变化可以评估心肌运动和收缩的空间分布。对于动脉壁，可以参考血压来评估其弹性。在活体实验中，评估了颈动脉壁厚度变化对硝酸甘油(NTG)剂量的快速反应。这一新的实时系统为定量诊断心肌运动、早期动脉粥样硬化以及瞬时评估心血管系统对生理应激的快速反应提供了可能性。

项目成果

Hiroshi KANAI, Yoshiro KOIWA: "PARCORR-Based Time-Dependent AR Spectrum Estimation of Heart Wall Vibration"IEICE Transactions on Fundamental of Electronics, Communications and Computer Sciences. Vol. E82-A, No. 4. 572-579 (1999)

Hiroshi KANAI、Yoshiro KOIWA：“基于 PARCORR 的心壁振动的时间相关 AR 频谱估计”IEICE 电子、通信和计算机科学基础交易。

H.Kanai,他3名: "Accuracy Evaluation in Ultrasonic-based Measurement of Microscopic Change in Thick-ness"Electronics Letters. 35. 949-950 (1999)

H. Kanai 等人：“基于超声波的厚度微观变化测量的精度评估”《电子快报》35. 949-950 (1999)。

中屋,金井,中鉢,本田,小岩: "超音波で計測した心臓壁微小振動の解析による左室拡張末期圧と心筋弾性値の非侵襲的計測"医用電子と生体工学. 37. 1-8 (1999)

Nakaya、Kanai、Cubachi、Honda、Koiwa：“通过分析超声测量的心壁微小振动来非侵入性测量左心室舒张末期压力和心肌弹性”《医疗电子与生物工程》37. 1-8 (1999)。 ）

Hiroshi KANAI: "Spectrum Analysis of Sound and Vibration"Corona Publishing Co., Ltd.. 1-328 (1999)

Hiroshi KANAI：《声音和振动的频谱分析》Corona Publishing Co., Ltd.. 1-328 (1999)

H.Hasegawa,H.Kanai,N.Hoshimiya,N.Chubachi,and Y.Koiwa:"“Accuracy Evaluation in Measurement of a Small Change in the Thickness of Arterial Walls and the Measurement of Elasticity of the Human Carotid Artery,"" Japanese Journal of Applied Physics. 37・5B. 31

H.Hasekawa、H.Kanai、N.Hoshimiya、N.Chubachi 和 Y.Koiwa：“动脉壁厚度微小变化测量和人体颈动脉弹性测量的准确性评估”日本应用物理学杂志。37・5B。