An Investigation on Noninvasive Measurement of Transmural Distribution of Myocardial Systolic Function and Diastolic Properties Using Ultrasound

超声无创测量心肌收缩功能和舒张功能透壁分布的研究

• 批准号: 15300177
• 负责人: KANAI Hiroshi
• 金额: $ 10.62万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15300177/
• 关键词: Ultrasonic Doppler method; Local change in thickness; Myocardial contraction; relaxation; Myocardial motility; Spectrum analysis; Color-coded display; Tissue Characterization; phased tracking method; 医用超音波工学; 心臓壁弾性特性; 非侵襲計測; 組織性状診断; 心臓壁粘性特性 /

For the serious heart diseases, the different transmural layers of the myocardium have transmural heterogeneity with respect to the strength of contraction. A method for measuring such transmural heterogeneity with sufficient spatial resolution has never been developed. In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed. Moreover, a novel method for measuring the myocardial viscoelasticity was developed and its principle was confirmed by the basic experiments and in vivo experiments as follows :1.In this study, a method for noninvasive measurement of the intramyocardial contraction/relaxation heterogeneity by evaluating the change in thickness or its speed in two dimensions and its measurement system were developed.2.Based on the basic experiments using a spherical shell made of silicone rubber, which physical parame … More ters are known, as a heart-mimicking phantom, the accuracy of the measurement of the developed method was confirmed.3.Moreover, this study developed the following novel method for noninvasively measuring the myocardial viscoelasticity at the beginning of diastole and for imaging the transmural heterogeneity in the propagation of the elastic waves. The method was applied to healthy subjects and patients with heart diseases. By this method, a velocity signal of the heart wall can be successfully detected with sufficient reproducibility. In this study, the pulsive waves were measured almost simultaneously at about 160 points set along the heart wall at a sufficiently high frame rate. The consecutive spatial phase distributions, obtained by the Fourier transform of the measured waves, clearly revealed wave propagation along the heart wall for the first time. Based on this phenomenon, we developed a means to measure the myocardial viscoelasticity in vivo using the model of the Lamb wave propagation in a viscoelastic plate. This method has a potential to noninvasively evaluate the myocardial viscoelasticity. Less

对于严重的心脏疾病，心肌的不同透壁层在收缩强度方面具有透壁异质性。测量这种跨壁异质性具有足够的空间分辨率的方法从来没有被开发。本研究开发了一种通过测量心肌厚度或其速度的二维变化来无创测量心肌收缩/舒张异质性的方法及其测量系统。在此基础上，提出了一种新的测量心肌粘弹性的方法，并通过基础实验和在体实验证实了其原理：1.本研究开发了一种通过测量心肌厚度变化或速度变化来无创测量心肌收缩/舒张不均匀性的方法及其测量系统; 2.在基础实验的基础上，采用硅橡胶球壳，测量了其物理参数，并对测量结果进行了分析和比较 ...更多信息 作为仿心脏体模，验证了该方法测量的准确性。3.此外，本研究还发展了以下新方法，用于无创测量心脏舒张初期的心肌粘弹性和成像弹性波传播中的跨壁不均匀性。该方法适用于健康受试者和心脏病患者。通过该方法，能够以充分的再现性成功地检测心壁的速度信号。在这项研究中，脉冲波几乎同时测量约160点设置沿着心脏壁在一个足够高的帧速率。连续的空间相位分布，通过傅立叶变换的测量波，清楚地揭示了波的传播沿着心脏壁的第一次。基于这一现象，我们发展了一种方法来测量心肌粘弹性在体内使用的模型中的兰姆波传播的粘弹性板。该方法具有无创性评价心肌粘弹性的潜力。少

项目成果

H.Kanai, Y.Koiwa, S.Katsumata, N.Izumi, M.Tanaka: "Measurement of rapid variation in ultrasound backscattering during change in thickness of tissue phantom"Japanese Journal of Applied Physics. 42. 3239-3245 (2003)

H.Kanai、Y.Koiwa、S.Katsumata、N.Izumi、M.Tanaka：“组织模型厚度变化期间超声反向散射快速变化的测量”日本应用物理学杂志。

K.Michishita, H.Hasegawa, H.Kanai: "Ultrasonic Measurement of Minute Displacement of Object Cyclically Actuated by Acoustic Radiation Force"Japanese Journal of Applied Physics. 42. 4608-4612 (2003)

K.Michishita、H.Hasekawa、H.Kanai：“声辐射力循环驱动物体微小位移的超声波测量”日本应用物理学杂志。

H.Kanai, H.Hasegawa, M.Ichiki, F.Tezuka, Y.Koiwa: "Elasticity Imaging of Atheroma with Transcutaneous Ultrasound -Preliminary Study-"Circulation. 107. 3018-3021 (2003)

H.Kanai、H.Hasekawa、M.Ichiki、F.Tezuka、Y.Koiwa：“经皮超声对动脉粥样硬化的弹性成像 - 初步研究 -”循环。

超音波を用いた対象物の局所ひずみ発生装置

使用超声波的物体局部应变发生器

• 发表时间: 2004

Transcutaneous Measurement of Myocardial Viscoelasticity

心肌粘弹性的经皮测量

• 发表时间: 2004
• 期刊: Proceedings of the Third International Conference on the Ultrasonic Measurement and Imaging of Tissue Elasticity
• 作者: Kanto Branch;The Society of Chemical Engineers;Japan(Ed.);Shinji Takeoka;Chemical Industry Co.;安井武史;Hiroshi Kanai
• 通讯作者: Hiroshi Kanai