A Study on Noninvasive Ultrasonic Measurement of Minute Mechanical-Excitation Wave-front Propagation in Human Myocardial Tissue and Its Visualization

人体心肌组织中微小机械激励波前传播的无创超声测量及其可视化研究

基本信息

  • 批准号:
    20360181
  • 负责人:
  • 金额:
    $ 11.98万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2008
  • 资助国家:
    日本
  • 起止时间:
    2008 至 2010
  • 项目状态:
    已结题

项目摘要

Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3-9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.
心脏收缩序列的复杂性仍然没有被完全理解,因为与收缩直接相关的动态机械激励过程不能基于电磁现象精确地测量。通过开发一种具有高时间和空间分辨率的非侵入性新型成像模式,本研究表明,机械波阵面的传播发生在心脏收缩序列的开始第一次(约60 ms之前,通常接受的收缩开始时间)。从室间隔的顶侧,产生振幅为几十微米的微小速度分量,并且其从后壁的顶点传播到基部,然后从基部传播到间隔的顶点,传播速度为3-9 m/s。这种动态测量模式也适用于生物学中的各种组织。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Artery-Wall Elasticity Imaging with Ultrasound
超声动脉壁弹性成像
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hideyuki Hasegawa;Hiroshi Kanai
  • 通讯作者:
    Hiroshi Kanai
Accurate ultrasonic measurement of two‐dimensional displacement of heart wall motion for estimation of myocardial regional strain rate
精确超声测量心壁运动二维位移估计心肌局部应变率
Lateral Motion Estimator for Measurement of Artery-Wall Displacement
用于测量动脉壁位移的横向运动估计器
  • DOI:
  • 发表时间:
    2009
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Hideyuki Hasegawa;Hiroshi Kanai
  • 通讯作者:
    Hiroshi Kanai
Optimal region-of-interest settings for tissue characterization based on ultrasonic elasticity imaging.
  • DOI:
    10.1016/j.ultrasmedbio.2007.10.005
  • 发表时间:
    2008-04
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    K. Tsuzuki;H. Hasegawa;M. Ichiki;F. Tezuka;H. Kanai
  • 通讯作者:
    K. Tsuzuki;H. Hasegawa;M. Ichiki;F. Tezuka;H. Kanai
Threshold setting for likelihood function for elasticity-based tissue classification of arterial wall by evaluating variance in measurement of radial strain
通过评估径向应变测量的方差来设置动脉壁基于弹性的组织分类的似然函数的阈值
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KANAI Hiroshi其他文献

High temporal resolution measurement of propagation pattern of myocardial stretching in left ventricle
左心室心肌拉伸传播模式的高时间分辨率测量
  • DOI:
    10.3179/jjmu.jjmu.a.177
  • 发表时间:
    2021
  • 期刊:
  • 影响因子:
    0
  • 作者:
    KUROKAWA Takafumi;NAKAJIMA Hiroyuki;TAKAHASHI Shinichiro;TANAKA Motonao;KANAI Hiroshi;SAIJO Yoshifumi
  • 通讯作者:
    SAIJO Yoshifumi

KANAI Hiroshi的其他文献

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{{ truncateString('KANAI Hiroshi', 18)}}的其他基金

A study on noninvasive ultrasonic measurement of visco-elastic property between blood pressure and strain
无创超声测量血压与应变粘弹性特性的研究
  • 批准号:
    17H02105
  • 财政年份:
    2017
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Study on visualization of defect of internal elastic lamina of arterial wall for diagnosis of very early-stage atherosclerosis
动脉壁内弹力层缺损可视化诊断极早期动脉粥样硬化的研究
  • 批准号:
    23650298
  • 财政年份:
    2011
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
A Study on Ultrasonic Measurement and Visualization of Propagation of Myocardial Contraction Response
心肌收缩反应传播的超声测量和可视化研究
  • 批准号:
    23360177
  • 财政年份:
    2011
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Research on diastolic properties of the myocardium by imaging propagation of shear wave along heart wall
剪切波沿心壁传播成像研究心肌舒张特性
  • 批准号:
    17206043
  • 财政年份:
    2005
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
An Investigation on Noninvasive Measurement of Transmural Distribution of Myocardial Systolic Function and Diastolic Properties Using Ultrasound
超声无创测量心肌收缩功能和舒张功能透壁分布的研究
  • 批准号:
    15300177
  • 财政年份:
    2003
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Simultanous Measurement of Velocity Signals at Multiple Points in the Heart Wall for Noninvasive Evaluation of Left Ventricular Inner Pressure and Elastic Modulus
同时测量心壁多点速度信号,无创评估左心室压力和弹性模量
  • 批准号:
    12650416
  • 财政年份:
    2000
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research and Development of System for Continuous Measurement of Transient Response of Arterial Wall to Administration of Nitroglycerine
连续测量动脉壁对硝酸甘油给药的瞬态反应系统的研制
  • 批准号:
    12555113
  • 财政年份:
    2000
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Research and Development of Medical Ultrasonic Equipment with Realtime Control of Ultrasonic Beam
超声束实时控制医用超声设备的研发
  • 批准号:
    10555134
  • 财政年份:
    1998
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Basic Problems of the Electrical Measurement of Biological Tissues
生物组织电学测量的基本问题
  • 批准号:
    10680803
  • 财政年份:
    1998
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Research on Cross-Sectional Imaging of Elasticity around Atherosclerotic Plaque with Transcutaneous Ultrasound
经皮超声对动脉粥样硬化斑块周围弹性的断面成像研究
  • 批准号:
    10650400
  • 财政年份:
    1998
  • 资助金额:
    $ 11.98万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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