A Study on Noninvasive Ultrasonic Measurement of Minute Mechanical-Excitation Wave-front Propagation in Human Myocardial Tissue and Its Visualization

人体心肌组织中微小机械激励波前传播的无创超声测量及其可视化研究

• 批准号: 20360181
• 负责人: KANAI Hiroshi
• 金额: $ 11.98万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20360181/
• 关键词: 心臓疾患; 医用超音波工学; 心臓壁弾性特性; 位相差トラッキング法; 電気的興奮伝搬; 合成開口法; 三次元表示; 心筋収縮弛緩特性; 合成開口洪

Complexity of the cardiac contraction sequence is still not fully understood because the dynamic mechanical excitation process, which directly correlates with contraction, cannot be accurately measured based on the electro-magnetic phenomena. By developing a noninvasive novel imaging modality with high temporal and spatial resolutions, the present study shows that the propagation of the mechanical wave-front occurs at the beginning of cardiac contraction sequence for the first time (about 60 ms prior to the ordinarily accepted onset time of the contraction). From the apical side of the interventricular septum, a minute velocity component with an amplitude of several tenth micrometers is generated and it propagates from the apex to the base of the posterior wall, and then from the base to the apex of the septum, with a propagation speed of 3-9 m/s. This dynamic measurement modality is also applicable to various tissues in biology.

由于与心脏收缩直接相关的动态机械激励过程无法根据电磁现象精确测量，因此心脏收缩序列的复杂性仍未完全了解。通过开发一种具有高时间和空间分辨率的无创新型成像方式，本研究表明，机械波前的传播发生在心脏收缩序列的第一次开始（比通常接受的收缩开始时间提前约60毫秒）。从室间隔顶侧产生振幅为十分之一微米的微小速度分量，从顶点向后壁基底传播，再从基底向室间隔顶传播，传播速度为3- 9m /s。这种动态测量方式也适用于生物学中的各种组织。

项目成果

Artery-Wall Elasticity Imaging with Ultrasound

超声动脉壁弹性成像

• 发表时间: 2010
• 作者: Hideyuki Hasegawa;Hiroshi Kanai
• 通讯作者: Hiroshi Kanai

Accurate ultrasonic measurement of two‐dimensional displacement of heart wall motion for estimation of myocardial regional strain rate

精确超声测量心壁运动二维位移估计心肌局部应变率

• DOI: 10.1121/1.2935445
• 发表时间: 2008
• 期刊: Journal of the Acoustical Society of America
• 影响因子: 2.4
• 作者: Y. Honjo;H. Hasegawa;H. Kanai
• 通讯作者: H. Kanai

Lateral Motion Estimator for Measurement of Artery-Wall Displacement

用于测量动脉壁位移的横向运动估计器

• 发表时间: 2009
• 作者: Hideyuki Hasegawa;Hiroshi Kanai
• 通讯作者: Hiroshi Kanai

Optimal region-of-interest settings for tissue characterization based on ultrasonic elasticity imaging.

• DOI: 10.1016/j.ultrasmedbio.2007.10.005
• 发表时间: 2008-04
• 期刊: Ultrasound in medicine & biology
• 影响因子: 2.9
• 作者: K. Tsuzuki;H. Hasegawa;M. Ichiki;F. Tezuka;H. Kanai

Threshold setting for likelihood function for elasticity-based tissue classification of arterial wall by evaluating variance in measurement of radial strain

通过评估径向应变测量的方差来设置动脉壁基于弹性的组织分类的似然函数的阈值

• 发表时间: 2008
• 期刊: Japanese Journal of Applied Physics Vol. 47, No. 5
• 作者: Kentaro Tsuzuki;Hideyuki Hasegawa;Hiroshi Kanai;Masataka Ichiki;and Fumiaki Tezuka
• 通讯作者: and Fumiaki Tezuka