Lesion Sterilization and Tissue Repair (LSTR) therapy for endodontic lesions including those of primary teeth at a physiologic root absorption stage

本项目旨在建立病灶灭菌和组织修复（LSTR） 3混合- mp治疗作为简单但仍然有效的根管治疗方法，包括那些处于生理性根吸收阶段的乳牙，根尖周围病变，这是公认的治疗难度较大的病例，通常是拔牙的病例。同时，对于农村和/或经济落后地区，由于传统治疗方法复杂、耗时长，有时效率较低，牙髓治疗不足的人群，也需要这样一种高效、省时的牙髓治疗方法。本研究项目取得的丰硕成果如下：1。通过牙本质携带混合抗菌药物（3Mix-MP）的载体效率评价：通过对丙二醇溶液中染料渗透的评价，发现丙二醇是比水更好的载体。12% EDTA的简单化学处理可以有效去除涂抹层，并提高3mix - mp的渗透效率。该疗法已在菲律宾（在3个地点治疗50多例）、孟加拉国（在3个地点治疗100多例）、泰国（在4个地点治疗300多例）、越南（在1个地点治疗10多例）、柬埔寨（在1个地点治疗10多例）和中国（在2个地点治疗60多例）以及日本应用。长期评估需要持续更长时间，但几乎所有病例在短期评估后都是临床良好的。在大多数情况下，无论临床症状和严重程度如何，只要一两次就诊就足以取得临床成功。由此可见，该疗法在牙科治疗中是非常有用的。

This project aimed to establish the Lesion Sterilization and Tissue Repair (LSTR) 3 Mix-MP therapy as simple but still efficient endodontic treatment, including those for primary teeth at a physiologic root absorption stage with periapical lesions, which are recognized to be rathertreatment-difficult and often to be the cases for extraction. At the same time, such an efficient and less time-consuming endodontic treatment has been needed for the people at rural areas and/or economically depressed areas where endodontic treatment has not been given enough because the conventional treatments are rather complicated, time-consuming and sometimes less efficient.The fruitful results in this research project are as follows ;1. Evaluation of efficiency of vehicles to carry mixed antibacterial drugs (3Mix-MP) through dentin : It was found that propylene glycol was a better vehicle than water,when estimated by means of dye-penetration solved in it. Simple chemical treatment with 12% EDTA was effective on removal of smear layers, and resulted in more efficient penetration of 3Mix-MP.3. The therapy has been applied in Philippines (at 3 sites for more than 50 cases), Bangladesh (at 3 sites for more than 100 cases),Thailand (at 4 sites for more than 300 cases), Vietnam (at 1 site for more than 10 cases), Cambodia (at 1 site for more than 10 cases) and China (at 2 sites for more than 60 cases) as well as in Japan. Long-term evaluations are going on for more years, but almost all cases were clinically good when evaluated after short-term. In most cases, only one or two visits were enough for the clinical success regardless the clinical symptoms and the seriousness.It can be concluded that the therapy is quite useful in dental treatments.