Lesion Sterilization and Tissue Repair (LSTR) therapy for endodontic lesions including those of primary teeth at a physiologic root absorption stage

该项目旨在建立病变灭菌和组织修复（LSTR）3 Mix-MP治疗作为简单但仍然有效的根管治疗，包括那些处于生理根吸收阶段的乳牙根尖周病变，这被认为是相当困难的治疗，往往是拔除的情况。与此同时，对于农村地区和/或经济不发达地区的人们来说，由于传统的治疗方法相当复杂、耗时，有时效率较低，因此需要这种高效且耗时更少的根管治疗。本研究项目的丰硕成果如下：1.混合抗菌药物（3 Mix-MP）载体的渗透性评价：通过染料渗透性评价，丙二醇是一种比水更好的载体; 12%EDTA的简单化学处理能有效去除玷污层，使3 Mix-MP更有效地渗透。该疗法已在菲律宾（3家研究中心，超过50例病例）、孟加拉国（3家研究中心，超过100例病例）、泰国（4家研究中心，超过300例病例）、越南（1家研究中心，超过10例病例）、柬埔寨（1家研究中心，超过10例病例）和中国（2家研究中心，超过60例病例）以及日本应用。长期评估持续了多年，但几乎所有病例在短期评估后临床表现良好。在大多数情况下，只要一次或两次的访问就足以获得临床成功，无论临床症状和严重程度如何，可以得出结论，该疗法在牙科治疗中是非常有用的。

This project aimed to establish the Lesion Sterilization and Tissue Repair (LSTR) 3 Mix-MP therapy as simple but still efficient endodontic treatment, including those for primary teeth at a physiologic root absorption stage with periapical lesions, which are recognized to be rathertreatment-difficult and often to be the cases for extraction. At the same time, such an efficient and less time-consuming endodontic treatment has been needed for the people at rural areas and/or economically depressed areas where endodontic treatment has not been given enough because the conventional treatments are rather complicated, time-consuming and sometimes less efficient.The fruitful results in this research project are as follows ;1. Evaluation of efficiency of vehicles to carry mixed antibacterial drugs (3Mix-MP) through dentin : It was found that propylene glycol was a better vehicle than water,when estimated by means of dye-penetration solved in it. Simple chemical treatment with 12% EDTA was effective on removal of smear layers, and resulted in more efficient penetration of 3Mix-MP.3. The therapy has been applied in Philippines (at 3 sites for more than 50 cases), Bangladesh (at 3 sites for more than 100 cases),Thailand (at 4 sites for more than 300 cases), Vietnam (at 1 site for more than 10 cases), Cambodia (at 1 site for more than 10 cases) and China (at 2 sites for more than 60 cases) as well as in Japan. Long-term evaluations are going on for more years, but almost all cases were clinically good when evaluated after short-term. In most cases, only one or two visits were enough for the clinical success regardless the clinical symptoms and the seriousness.It can be concluded that the therapy is quite useful in dental treatments.