Ecological approach to periodontal pocket plaque control.

牙周袋菌斑控制的生态方法。

• 批准号: 07307018
• 负责人: HOSHINO Etsuro
• 金额: $ 1.34万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07307018/
• 关键词: periodontal pockets; plaque control; oral microflora; ecology; anaerobes; 細菌叢

Quantitative and qualitative controls of microflora in periodontal pockets are of benefit to prevent the onset or progress of periodontal disease, since bacteria in periodontal pockets play pathogenic roles in periodontal diseases. To control, ecological understanding of the microflora is essential.Anaerobic and proteolyic conditions were the ecological characteristics of periodontal pockets, and overwhelming majority of the flora was constituted by anaerobic, asaccharolytic bacteria, some of which should be classified to new genera or species.According to these characteristics, co-aggregation factors, plasmids, and antibacterial enzymes, drugs and agents, as well as the removal of pockets itself, were considered for the quantitative and qualitative controls of microflora in periodontal pockets.

由于牙周袋内的细菌在牙周病中起致病作用，因此，对牙周袋内的微生物群落进行定量和定性控制有利于预防牙周病的发生或发展。为了控制牙周病，必须了解微生物植物群的生态学特征。厌氧和蛋白水解条件是牙周袋的生态学特征，绝大多数植物群是由厌氧的、溶砷的细菌组成的，其中一些应被分类为新的属或种。根据这些特征，共聚集因子、质粒、抗菌酶、药物和制剂，以及去除牙周袋本身，被认为是牙周袋中微生物群落的定量和定性控制。

项目成果

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Shinichi Nakamura：“从中间普雷沃氏菌中分离出的血凝因子和溶血因子的特性”牙科 59. 333-343 (1996)。

Umemoto, T.: "Treponema medium sp. nov. isolated from subgingival dental plaque" International Journal of Systematic Bacteriology. 47. 67-72 (1997)

Umemoto, T.：“从龈下牙菌斑中分离出新种密螺旋体”《国际系统细菌学杂志》。

Uematsu H.: "Degradation of arginine and the other amino acids by Eubacterium nodatum ATCC 33099." Microbial Ecology in Health and Disease. 10(in press). (1997)

Uematsu H.：“结节真杆菌 ATCC 33099 降解精氨酸和其他氨基酸。”

Uematsu H.: "Degradation of arginine and the other amino acids by Eubacterium nodatum ATCC 33099" Microbial Ecology in Health and Disease. 10(印刷中). (1997)

Uematsu H.：“真杆菌 ATCC 33099 对精氨酸和其他氨基酸的降解”《健康与疾病微生物生态学》10（出版中）。

Md. Abdul Hamid: "Inhibitory effects of metronidazole in anaerobic metabolism of phenylalanine and leucine by resting cells of Peptostreptococcus anaerobius." Journal of Antimicrobial Chemotherapy. 39(印刷中). (1997)

阿卜杜勒·哈米德博士：“甲硝唑对消化链球菌静息细胞无氧代谢的抑制作用”，《抗菌化疗杂志》39（出版中）。