New culture-difficult oral bacterial species, Eubacterium saphenum and its periodontitis-pathogenic characteristics.

口腔新培养难菌种、隐真杆菌及其牙周炎致病特征。

• 批准号: 07457427
• 负责人: HOSHINO Etsuro
• 金额: $ 0.64万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457427/
• 关键词: Eubacterium saphenum; periodontal diseasen; adult periodontitis; asaccharolytic Eubacterium; cultur-difficult bacteria

It has been recognized since system for obligate anaerobic bacteria was established recently that culture-difficult bacteria were overwhelming in oral bacterial florae. Many of them recently isolated successfully were anaerobic, asaccharolytic gram-positive rods which would be classified to Genus Eubacterium according to the present criteria. One of them was E.saphenum which has been isolated as predominant bacteria from periodontal pockets with adult periodontitis and distributed commonly among the patients.In order to clarify the bacterial characteristics, several kinds of new culture-difficult bacteria were isolated from various oral sites to compare their characteristics with that of E.saphenum, and found that they could be grouped as several new unreported strains which should be proposed for the new genera or species. Immunological association of this bacterial species with adult periodontites was suggested by high titers of serum antibody against E.saphenum in the patients with adult periodontitis.

近年来专性厌氧菌体系建立以来，人们认识到难培养菌在口腔菌群中占绝对优势。最近成功分离的许多菌株是厌氧的、溶砷的革兰氏阳性杆菌，根据目前的标准将其分类为真杆菌属（Eubacterium）。为明确隐球菌的细菌学特征，本研究从成人牙周炎患者的牙周袋中分离出几种新的难培养菌，并与隐球菌进行比较，并发现它们可归为几个新的未报道的菌株，应建议为新属或新种。成人牙周炎患者血清中抗隐球菌抗体滴度较高，提示隐球菌与成人牙周炎存在免疫相关性。

项目成果

Poco Jr., S. E.: "Eubacterium exiguum sp. nov. isolated from human oral lesions." International Journal of Systematic Bacteriology. 46. 1120-1124 (1996)

Poco Jr.，S.E.：“从人类口腔病变中分离出的 Exiguum sp. nov.”。

KANAZAWA F.: "Newly classified oral bacteria" Niigata Dental Journal. 25. 61-62 (1995)

KANAZAWA F.：“新分类的口腔细菌”新泻牙科杂志。

Nakazawa F.: "Newly classified oral bacteria" Niigata Dental Journal. 25. 61-62 (1995)

Nakazawa F.：“新分类的口腔细菌”《新泻牙科杂志》。

Sato, T.,: "Eubacterium saphenum isolated from human periodontal pockets" Science Review, 1995. 33-37 (1995)

Sato, T.，：“从人类牙周袋中分离出隐芽真杆菌”《科学评论》，1995 年。 33-37 (1995)

Poco Jr., S. E.: "Eubacterium minutum sp. nov. isolated from human periodontal pockets." International Journal of Systematic Bacteriology. 46. 31-34 (1996)

Poco Jr.，S.E.：“从人类牙周袋中分离出的微小真杆菌新种”。