Conservation and Analyzes of Genetic Information of Asian Ethnic Groups
Conservation and Analyzes of Genetic Information of Asian Ethnic Groups
批准号:
12575015
负责人:
ISHIDA Takafumi
金额:
$10.11万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2000
资助国家:
日本
项目状态:
已结题
起止时间:
2000 至 2002
中文摘要
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英文摘要
The aim of this study is to conserve genetic information of Asian ethnic groups especially small sized populations in the form of a cell bank and DNA bank. For this, we have conducted field studies in Indonesia, Malaysia and Thailand.1. Field study: for the population genetic study, specimens were collected from Sumbanese, Timorese, Moken and Mani. A total of 400 specimens were collected and 250 cell lines were established.2. Study on Genome diversity: Polymorphisms of the following genes, SDF1, MC1R, AIMland p53, were studied among these populations with other Asian and Oceanian populations.3. Malaria related genes: Prevalence of 27-bp deletion of the 3 protein gene arid G6PD deficiency was studied in Sumbanese in the presence of the parasitemia data.4. Epstein-Barr virus associated peripheral T-cell proliferative diseaseis: A rapid and sensitive plasma DNA test for this disease entity was established.
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Kimura, R. et al.: "The SDF1-G801A polymorphism is not associated with SDF1 gene expression in Epstein-Barr virus-transformed lymphoblastoid cells"Genes and Immunity. (in press). (2003)
Kimura, R. 等人:“SDF1-G801A 多态性与 Epstein-Barr 病毒转化的淋巴母细胞中的 SDF1 基因表达无关”《基因与免疫》。
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Shimizu,Y., et al.: "Sero-and Molecular Typing of Duffy Blood Group in Southeast Asians and Oceanians."Human Biology. 72(3). 511-518 (2000)
Shimizu,Y., et al.:“东南亚和大洋洲人达菲血型的血清和分子分型。”人类生物学。
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Mori, A., Takao, S.et al.: "High tumor necrosis factor-a levels in the patients with Epstein-Barr virus-associated peripheral T-cell proliferative disease/lymphoma"Leukemia Research. 27. 493-498 (2003)
Mori, A.、Takao, S.等人:“Epstein-Barr 病毒相关外周 T 细胞增殖性疾病/淋巴瘤患者的肿瘤坏死因子 -a 水平较高”白血病研究。
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Kimura, M., Soemantri, Ag., Ishida, T.: "Malaria species and Southeast Asian ovalocytosis defined by a 27-bp deletion in the erythrocyte band 3 gene"Southeast Asian Journal of Tropical Medicine and Public Health. 33. 4-6 (2002)
Kimura, M.、Soemantri, Ag.、Ishida, T.:“疟疾种类和东南亚卵形细胞增多症由红细胞带 3 基因中的 27-bp 缺失定义”《东南亚热带医学与公共卫生杂志》。
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共 27 条
Reactivation of latently infected virus as a novel non-invasive stress marker
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批准号:23657170
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.5万
-
财政年份:2011
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负责人:ISHIDA Takafumi
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依托单位:
Bach1 as a therapeutic target for ischemic cardiovascular diseases
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批准号:23590381
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.24万
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财政年份:2011
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负责人:ISHIDA Takafumi
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依托单位:
HOMINIZATION IN LIFESPAN AND ADAPTATION
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批准号:21247039
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$29.95万
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财政年份:2009
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负责人:ISHIDA Takafumi
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依托单位:
Role of transcription repressor Bach1 in cardiovascular diseases
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批准号:19590561
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:ISHIDA Takafumi
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依托单位:
Genome stability and primate lifespan
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批准号:18370097
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.59万
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财政年份:2006
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负责人:ISHIDA Takafumi
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依托单位:
Genetic and ecologic background and resistance to malaria
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批准号:18406025
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.25万
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财政年份:2006
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负责人:ISHIDA Takafumi
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依托单位:
The role of MNK1/2 in cardiovascular remodeling
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批准号:17590737
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:2005
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负责人:ISHIDA Takafumi
-
依托单位:
The function of Mnk1 in vascular smooth muscle cells
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批准号:15590750
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2003
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负责人:ISHIDA Takafumi
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依托单位:
Molecular Basis of Human Skim and Primate Hair Color Variation
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批准号:14340273
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:2002
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负责人:ISHIDA Takafumi
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依托单位:
Establishment of an animal model for human cellular againg
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批准号:11554038
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$5.12万
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财政年份:1999
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负责人:ISHIDA Takafumi
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依托单位:
Microevolution and genetic adaptation among Asians
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批准号:10440254
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.91万
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财政年份:1998
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负责人:ISHIDA Takafumi
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依托单位:
Genetic diversity and adaptation among Southeast Asians
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批准号:09041148
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$6.34万
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财政年份:1997
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负责人:ISHIDA Takafumi
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依托单位:
海外基金