HOMINIZATION IN LIFESPAN AND ADAPTATION

寿命和适应的人化

• 批准号: 21247039
• 负责人: ISHIDA Takafumi
• 金额: $ 29.95万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21247039/
• 关键词: ゲノム; バイオリソース; 適応; ヒト化; ゲノム維持; 老化; 細胞; ｐ５３; ＧＳＴ

Mammalian cell and DNA repository was established for more than 100 species. Primate p53 genes were highly conserved in the coding regions; however,cellular constraints on the p53 modification during cell senescence were strengthened along hominization. In humans, p53 codon 72 polymorphism is ubiquitously observed with a variety of frequencies; a meta-analysis for this polymorphism suggested an association between its prevalence and UV.

为100多个物种建立了哺乳动物细胞和DNA储存库。灵长类p53基因的编码区高度保守，然而，细胞衰老过程中的p53修饰的细胞约束加强沿着人化。在人类中，p53密码子72多态性是普遍观察到的各种频率;对这种多态性的荟萃分析表明，其患病率和紫外线之间的关联。

项目成果

Differential Prefrontal White Matter Development in Chimpanzees and Humans

• DOI: 10.1016/j.cub.2011.07.019
• 发表时间: 2011-08
• 期刊: Current Biology
• 影响因子: 9.2
• 作者: Tomoko Sakai;A. Mikami;M. Tomonaga;M. Matsui;J. Suzuki;Y. Hamada;Masayuki Tanaka;T. Miyabe-Nishiwaki;Haruyuki Makishima;M. Nakatsukasa;T. Matsuzawa

DRD4 VNTR polymorphism in Oceanic populations

• DOI: 10.1537/ase.110901
• 发表时间: 2012-02
• 期刊: Anthropological Science
• 影响因子: 0.7
• 作者: I. Naka;J. Ohashi;R. Kimura;Takuro Furusawa;T. Yamauchi;M. Nakazawa;K. Natsuhara;Y. Ataka;N. Nishida;T. Ishida;T. Inaoka;Y. Matsumura;R. Ohtsuka

The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome.

• DOI: 10.1371/journal.pone.0038379
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kurosaki T;Ueda S;Ishida T;Abe K;Ohno K;Matsuura T
• 通讯作者: Matsuura T

Variations in the Coding Region of the Agouti Signaling Protein Gene Do Not Explain Agouti/Non-agouti Phenotypes in Macaques

• DOI: 10.1007/s10914-010-9137-7
• 发表时间: 2010-04
• 期刊: Journal of Mammalian Evolution
• 影响因子: 1.9
• 作者: Kazuhiro Nakayama;T. Shotake;Osamu Takeneka;T. Ishida

Spontaneous T/NK-cell lymphoma associated with Simian Lymphocryptovirus in a Japanese Macaque (Macaca fuscata).

日本猕猴（Macaca fuscata）中与猿猴淋巴隐病毒相关的自发性 T/NK 细胞淋巴瘤。

• DOI: 10.1016/j.jcpa.2012.05.001
• 发表时间: 2013
• 期刊: Journal of Comparative Pathology
• 作者: Hirata A;Tachikawa Y;Hashimoto K;Sakai H;Kaneko A;Suzuki J;Eguchi K;Shigematsu K;Nikami H;and Yanai T.
• 通讯作者: and Yanai T.