Reactivation of latently infected virus as a novel non-invasive stress marker

潜伏感染病毒的重新激活作为新型非侵入性应激标记

• 批准号: 23657170
• 负责人: ISHIDA Takafumi
• 金额: $ 2.5万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23657170/
• 关键词: ストレス評価; ウイルス; 非侵襲; ストレスマーカー; 社会的ストレス; アミラーゼ; 潜伏ウイルス; 再活性化; ストレス指標; 人類; 霊長類

To search for novel non-invasive stress marker(s), reactivation of latently infected ubiquitous viruses and salivary alpha-amylase were monitored. The concentrations of salivary alpha-amylase among several animals such as elephants, chimpanzees, horses, were measurable with a simple machine produced for human amylase monitoring. Shedding pattern of the human gamma-herpesvirus (EBV) into saliva delayed the changes of alpha-amylase concentration; reactivation of EBV (or gamma-herpesvirus) is considered to be a medium-range stress marker.

为了寻找新的非侵入性应激标志物，监测潜伏感染的普遍存在的病毒和唾液α-淀粉酶的再活化。用一种简单的用于人体淀粉酶监测的仪器，可以测量几种动物如大象、黑猩猩、马的唾液α-淀粉酶浓度。 人类γ-疱疹病毒（EBV）进入唾液的脱落模式延迟了α-淀粉酶浓度的变化; EBV（或γ-疱疹病毒）的再活化被认为是一种中等范围的应激标志物。

项目成果

The unstable CCTG repeat responsible for myotonic dystrophy type 2 originates from an AluSx element insertion into an early primate genome.

• DOI: 10.1371/journal.pone.0038379
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kurosaki T;Ueda S;Ishida T;Abe K;Ohno K;Matsuura T
• 通讯作者: Matsuura T

Human papillomavirus genotype and cervical cancer in Northeast Thailand

泰国东北部的人乳头瘤病毒基因型与宫颈癌

• 期刊: Asian Pacific Journal of Cancer Prevention
• 作者: Natphopsuk;S.;Settheetham-Ishida;W.,Pientong,C.;Sinawat;S.;Yuenyao;P. and Ishida;T
• 通讯作者: T

Current advances in gibbon phylogeny

长臂猿系统发育的最新进展

• 发表时间: 2012
• 作者: Matsudaira;K. and Ishida;T
• 通讯作者: T

Molecular evolution of immunoglobulin superfamily genes in primates

• DOI: 10.1007/s00251-011-0519-7
• 发表时间: 2011-07-01
• 期刊: IMMUNOGENETICS
• 影响因子: 3.2
• 作者: Ohtani, Hitoshi;Nakajima, Toshiaki;Kimura, Akinori
• 通讯作者: Kimura, Akinori

Direct evidence for Toxoplasma gondii infection in a wild Japanese serow (Capricornis crispus) from mainland Japan

来自日本大陆的野生日本鬣羚（摩羯座）感染弓形虫的直接证据

• DOI: 10.1645/ge-2881.1
• 发表时间: 2012
• 期刊: J. Parasitology
• 作者: Sakae;C. and Ishida;T
• 通讯作者: T