Molecular Basis of Human Skim and Primate Hair Color Variation

人类脱毛和灵长类动物毛发颜色变化的分子基础

• 批准号: 14340273
• 负责人: ISHIDA Takafumi
• 金额: $ 8.32万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14340273/
• 关键词: Human; Macaque; Gibbon; Primates; Body Color; Gene; 毛色; MC1R; AIM1; ASIP; 皮膚色; 遺伝的多型

Population based molecular studies and pharmacological analyses have revealed that the polymorphisms of the MClR are strongly associated with skin color variation in Asians and Oceanians. Nonsynonymous substitutions found in northeastern Asian population reduced cAMP production levels.Distribution of one of the polymorphisms of the ALMl, Leu374Phe, was exclusively limited to Caucasian stocks, although 374^<Pbe> is ubiquitously found through the plant and vertebrates.In other primates, such as macaques and gibbons, participation of the MClR and agouti in their coat color determination was suggested with special reference to their ecological and evolutionary status.

基于人群的分子生物学研究和药理学分析表明，MClR的多态性与亚洲人和大洋洲人的肤色变化密切相关。在东北亚人群中发现的非同义替换降低了cAMP的产生水平。ALM1的多态性之一Leu374 Phe的分布仅限于高加索种群，尽管374 Phe在植物和脊椎动物中普遍存在。在其他灵长类动物中，如猕猴和长臂猿<Pbe>，根据它们的生态和进化地位，提出了MClR和Agglutination参与毛色决定的观点。

项目成果

Sugawara, H. et al.: "Complex low-copy repeats associated with a common polymorphic inversion at human chromosome 8p23"Genomics. 82. 238-244 (2003)

Sukawara, H. 等人：“与人类染色体 8p23 处常见多态性倒位相关的复杂低拷贝重复”基因组学。

Nakayarna, K., Fukamachi, S., Kimura, H., Koda, Y., Soemantri, Ag., Ishida, T.: "Distinctive distribution of AIMl polymophism among major human populations with different skin color."Journal of Human Genetics. 47. 92-94 (2002)

Nakayarna, K.、Fukamachi, S.、Kimura, H.、Koda, Y.、Soemantri, Ag.、Ishida, T.：“AIM1 多态性在不同肤色的主要人群中的独特分布。”人类遗传学杂志

Shimizu, Ishida: "Somatic mutations in the p53 gene account for the extention of replicative life-span of macague cells."Biochem.Biophys.Res.Commun.. 295. 644-650 (2002)

Shimizu, Ishida：“p53 基因的体细胞突变导致猕猴细胞复制寿命的延长。”Biochem.Biophys.Res.Commun.. 295. 644-650 (2002)

Tachikui, H., Nakajima, T., Saitou, N., Hayasaka, I., Ishida, T., Inoue, I.: "Lineage specific homogenization of the polyubiquitin gene among human and great apes."Molecular Biology and Evolution. Journal of Molecular Evolution. 57. 737-744 (2003)

Tachikui, H.、Nakajima, T.、Saitou, N.、Hayasaka, I.、Ishida, T.、Inoue, I.：“人类和类人猿中多泛素基因的谱系特异性同质化。”分子生物学与进化。

Shimizu et al.: "In vitro aging of macaque adherent cells : similar pattern of cellular aging between human and macague."Mechanisms of Ageing and Development. 124. 243-250 (2003)

Shimizu 等人：“猕猴贴壁细胞的体外衰老：人类和猕猴之间细胞衰老的相似模式。”衰老和发育的机制。