Bach1 as a therapeutic target for ischemic cardiovascular diseases

Bach1是一种应激反应转录因子，它协调细胞保护因子的表达水平，包括血红素加氧酶(HO)-1。在本研究中，我们研究了抑制Bach1表达对小鼠心肌梗死和肢体缺血后心脏重构的影响。在Bach1基因缺陷的小鼠中，心肌梗死后的不良心脏重构和纤维化显著减轻。在后肢缺血模型中，肌肉内注射针对Bach1的siRNA加速了血流灌流和毛细血管密度。这些结果表明，Bach1的表达可以作为治疗缺血性心血管疾病的靶点。

Bach1 is a stress-responsive transcriptional factor that orchestrates the expression levels of cytoprotective factors, including heme-oxygenase (HO)-1. In the present study, we investigated the effect of suppression of Bach1 expression on cardiac remodeling after myocardial infarction and limb ischemia in mice. Adverse cardiac remodeling and fibrosis after myocardial infarction was significantly attenuated in Bach1-deficient mice. Intramuscular administration of siRNA against Bach1 accelerated blood flow perfusion and capillary density in a hindlimb ischemia model. These results suggest that Bach1 expression can be a therapeutic target in ischemic cardiovascular diseases.