Bach1 as a therapeutic target for ischemic cardiovascular diseases

Bach1作为缺血性心血管疾病的治疗靶点

• 批准号: 23590381
• 负责人: ISHIDA Takafumi
• 金额: $ 3.24万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590381/
• 关键词: 心血管疾患; RNA干渉; 酸化ストレス; 酸化ストレス応答; 虚血

Bach1 is a stress-responsive transcriptional factor that orchestrates the expression levels of cytoprotective factors, including heme-oxygenase (HO)-1. In the present study, we investigated the effect of suppression of Bach1 expression on cardiac remodeling after myocardial infarction and limb ischemia in mice. Adverse cardiac remodeling and fibrosis after myocardial infarction was significantly attenuated in Bach1-deficient mice. Intramuscular administration of siRNA against Bach1 accelerated blood flow perfusion and capillary density in a hindlimb ischemia model. These results suggest that Bach1 expression can be a therapeutic target in ischemic cardiovascular diseases.

Bach 1是一种应激反应转录因子，其协调细胞保护因子（包括血红素加氧酶（HO）-1）的表达水平。在本研究中，我们研究了抑制Bach 1表达对小鼠心肌梗死和肢体缺血后心脏重构的影响。在Bach 1缺陷小鼠中，心肌梗死后的不良心脏重塑和纤维化显著减弱。肌内注射针对Bach 1的siRNA加速了后肢缺血模型中的血流灌注和毛细血管密度。这些结果表明，Bach 1表达可以成为缺血性心血管疾病的治疗靶点。

项目成果

The effect of ezetimibe on lipid and glucose metabolism in patients with hypercholesterolemia.

依折麦布对高胆固醇血症患者脂质和糖代谢的影响。

• 发表时间: 2013
• 作者: 近藤 小貴;前川 文;鈴木 まりこ;鐘ヶ江 裕美;石田 隆史
• 通讯作者: 石田 隆史

Association of elevated plasma aldosterone-to-renin ratio with future cardiovascular events in patients with essential hypertension

• DOI: 10.1097/hjh.0b013e328359862d
• 发表时间: 2012-12-01
• 期刊: JOURNAL OF HYPERTENSION
• 影响因子: 4.9
• 作者: Kisaka, Tomohiko;Ozono, Ryoji;Kihara, Yasuki
• 通讯作者: Kihara, Yasuki

Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms

腹主动脉瘤形成过程中平滑肌细胞中 Timp1 的诱导

• 发表时间: 2013
• 期刊: Hiroshima J Med Sci
• 作者: Bumdelger B;Kokubo H;Kamata R;Fujii M;Ishida M;Ishida T;Yoshizumi M
• 通讯作者: Yoshizumi M

Reorganization of Damaged Chromatin by the Exchange of Histone Variant H2A.Z-2

• DOI: 10.1016/j.ijrobp.2014.03.031
• 发表时间: 2014-07-15
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Nishibuchi, Ikuno;Suzuki, Hidekazu;Tashiro, Satoshi
• 通讯作者: Tashiro, Satoshi

Species differences of macrophage very low-density-lipoprotein (VLDL) receptor protein expression

• DOI: 10.1016/j.bbrc.2011.03.069
• 发表时间: 2011-04-22
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Takahashi, Sadao;Ito, Takashi;Shiomi, Masashi
• 通讯作者: Shiomi, Masashi