The molecular epidemiological analyses of G6PD deficiency in Vietnam

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The cooperative research of molecular epidemiological analyses of G6PD deficiency in Vietnam between Dao's group and our group has been developed. Within 3 years of this project, we could collect the dried blood samples (5,899) from newborn babies in Hanoi and screen them by our Formazan method. The positive incidence of G6PD deficiency was 3.1 %. This value was nearly same in Filipinos. However, its value from Hor Binh Province near Hanoi was 18 % and especially from Muong nations in Hor Binh, 32 %.From northern (Hanoi, Hoa Binh), central (Khanh Hoa, Hue) and southern Vietnam (Ho Chi Minh City) we could collect 137 samples for genomic analyses by MPTP method with their informed consent. Those contained Kinh, Muong, Katu, Dao, Raclei and Tay nations. Seven different variations such as Gaoha, Chatham, Chinese 5, Viangchan, Union, Canton and Kaiping could be identified. Union was major in Muong and Viangchan in Katu. These variants were popular in neighboring countries of Indonesia, Malaysia, Singapore, Philippines and Thailand. But from Vietnamese we could hardly obtain the variants of Mahidol, Mediterranean and Vanua Lava.