权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Significant of masticatory exercise in defensive reaction to stress

咀嚼运动对压力防御反应的意义

基本信息

批准号：
13470408
负责人：
WATANABE Makoto
金额：
$ 6.66万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470408/
关键词：
Stress Temporomandibular disorders Occlusion Bite

项目摘要

There is a possibility that the reaction to stress relates to the cause of the illness. Temporomandibular disorders (TMD) are typical symptoms that are thought to be due to muscle fatigue resulting from abnormal masticatory exercise (such as bruxism resulting from stress) or from improper occlusion. However, the mechanisms underlying these events in skeletal muscle have yet to be established. During some earlier experiments on restraint stress in mice, we noticed an interesting type of behavior. When a mouse is put into a narrow cylinder in which it is unable to turn (the front end being partially closed with a thin, colorless plastic strip, and the back end closed with tape), the mouse gnaws away at the plastic strip. The mouse can move back and forth within the cylinder and freely chooses to bite the plastic strip. However, if its tail is fastened to the back end of the cylinder by tape, the mouse cannot reach the strip and therefore cannot bite it. Using these two variations of the method, we could examine the effects of restraint with or without gnawing (R+G+ and R+G-, respectively). We hypothesize that the effects of gnawing behavior reduces reaction to psychological stress. We examined Whether the gnawing behavior reduced the restraint-induced elevation of serum glucocorticoids or cortisol. As a result R+G+ mice showed a smaller elevation of serum cortisol than that shown by R+G- mice. Thus, R+G- may produce more frustration than R+G+, leading the mouse to produce more glucocorticoids. We measured the total weight of plastic gnawed away up to a given time-point as an index of cumulative gnawing activity (CGA), and the weight of plastic lost per 2-h period as the rate of gnawing. We took notice of time of day on CGA in mice. As a result, CGA was significantly greater in the nighttime hours than in the daytime. In conclusion, our results cold suggest that gnawing behavior reduces reaction to psychological stress.

对压力的反应可能与疾病的原因有关。颞下颌关节紊乱病（TMD）是一种典型的症状，被认为是由于咀嚼运动异常（如压力引起的磨牙症）或咬合不正确引起的肌肉疲劳。然而，骨骼肌中这些事件的潜在机制尚未建立。在一些早期的小鼠束缚应激实验中，我们注意到一种有趣的行为。当一只老鼠被放入一个狭窄的圆柱体中时，它无法转动（前端用一条薄的无色塑料条部分封闭，后端用胶带封闭），老鼠会啃咬塑料条。鼠标可以在圆筒内来回移动，并自由选择咬塑料条。然而，如果用胶带将老鼠的尾巴固定在圆柱体的后端，老鼠就不能够到胶带，因此不能咬它。使用这两种方法的变体，我们可以检查有或没有啃咬的约束效果（分别为R+G+和R+G-）。我们假设啃咬行为的影响降低了对心理压力的反应。我们研究是否啃行为减少限制引起的血清糖皮质激素或皮质醇的升高。结果，R+G+小鼠的血清皮质醇升高幅度小于R+G-小鼠。因此，R+G-可能比R+G+产生更多的挫折，导致小鼠产生更多的糖皮质激素。我们测量了在给定时间点被啃掉的塑料的总重量作为累积啃咬活性（CGA）的指数，并且每2小时的塑料损失的重量作为啃咬速率。我们注意到小鼠CGA的一天中的时间。结果，夜间的CGA显著大于白天。总之，我们的研究结果表明，啃咬行为减少了对心理压力的反应。