Application of Super High-Purity Iron for Dental Treatment

牙科金属作为修复材料，提高了患者的生活质量。然而，需要更安全的替代材料，因为有几种口腔疾病可能由牙科金属引起。日本东北大学材料研究所研制出了世界上独一无二的新一代材料“超高纯度铁（UHP-Fe）”。我们还开发了一种新的生物材料安全性测试方法，用于实验动物模型的评估。在本研究中，我们的目的是通过体内安全性试验来检验UHP-Fe在临床应用中是否对更安全的生物材料有价值。我们将UHP-Fe金属丝皮下注射到小鼠体内，5天后我们获得了金属丝周围组织的包埋。为了研究金属离子在体内的洗脱，我们将周围组织溶解，并用质谱分析金属离子定量分析技术（ICP-MS法）对溶液进行分析。此外，通过扫描电子显微镜（SEM）检测了金属表面的腐蚀情况。超高纯度铁的表面几乎没有腐蚀，皮下组织未见炎症。因此，超高纯度铁是一种安全的生物材料，预示着它将在未来成为一种新的医用生物材料。

Dental metal has increased the patient's QOL as a repair material. However, safer alternative materials are desired, because there is a possibility that several oral disease may be caused by dental metal. The "ultra-high purity iron (UHP-Fe)" that is the next-generation material unparalleled in the world has been generated in the Institute for Materials Research at Tohoku University. We also developed the novel safety test for evaluating biomaterials using experimental animal model. In this study, our purpose is to examine whether UHP-Fe is valuable for safer biomaterials in the clinical application using the safety test in vivo. We injected the wire of UHP-Fe into the mice subcutaneously, Five days later we obtained the surrounding tissue embedded in the metal wire. To investigate the elution of metal ions in the in vivo, we were dissolved the surrounding tissue and the solution was analyzed by mass spectrum analysis metal ions quantitative analysis technique (ICP-MS method). In addition, the removed wires were detected the corrosion of metal surfaces by scanning electron microscopy (SEM method). There is almost no corrosion of the surface ultra-high purity iron and inflammation of the subcutaneous tissue was not observed. Therefore, ultra-high purity iron is a safe biological material, suggesting that it will become a new medical biomaterial in the future.