Application of Super High-Purity Iron for Dental Treatment

超高纯铁在牙科治疗中的应用

• 批准号: 23659894
• 负责人: WATANABE Makoto
• 金额: $ 2.33万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659894/
• 关键词: 超高純度鉄; 臨床応用; in vivo 安全性試験; 加工技術; 代替材料; 安全性試験; 革新技術

Dental metal has increased the patient's QOL as a repair material. However, safer alternative materials are desired, because there is a possibility that several oral disease may be caused by dental metal. The "ultra-high purity iron (UHP-Fe)" that is the next-generation material unparalleled in the world has been generated in the Institute for Materials Research at Tohoku University. We also developed the novel safety test for evaluating biomaterials using experimental animal model. In this study, our purpose is to examine whether UHP-Fe is valuable for safer biomaterials in the clinical application using the safety test in vivo. We injected the wire of UHP-Fe into the mice subcutaneously, Five days later we obtained the surrounding tissue embedded in the metal wire. To investigate the elution of metal ions in the in vivo, we were dissolved the surrounding tissue and the solution was analyzed by mass spectrum analysis metal ions quantitative analysis technique (ICP-MS method). In addition, the removed wires were detected the corrosion of metal surfaces by scanning electron microscopy (SEM method). There is almost no corrosion of the surface ultra-high purity iron and inflammation of the subcutaneous tissue was not observed. Therefore, ultra-high purity iron is a safe biological material, suggesting that it will become a new medical biomaterial in the future.

牙科金属作为修复材料，提高了患者的生活质量。然而，需要更安全的替代材料，因为牙科金属可能会导致几种口腔疾病。东北大学材料研究所开发出了世界上独一无二的下一代材料“超高纯铁（UHP-Fe）”。我们还开发了一种新的安全性测试，用于评估生物材料使用实验动物模型。在这项研究中，我们的目的是检查是否UHP-Fe是更安全的生物材料在临床应用中使用体内安全性测试的价值。我们将超高压铁丝注射到小鼠皮下，5天后我们获得了包埋在金属丝周围的组织。为了研究金属离子在体内的洗脱情况，我们溶解周围组织，并通过质谱分析金属离子定量分析技术（ICP-MS法）对溶液进行分析。此外，通过扫描电子显微镜（SEM）方法检测了去除的金属丝表面的腐蚀情况。超高纯铁表面几乎没有腐蚀，皮下组织也没有炎症。因此，超高纯铁是一种安全的生物材料，预示着它将成为未来一种新的医用生物材料。

项目成果

金属アレルギーにおける免疫制御

金属过敏的免疫调节

• 发表时间: 2012
• 作者: 小笠原康悦