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Study of adaptability to oral environmental changes from brain plasticity perspective

从大脑可塑性角度研究口腔环境变化的适应性

基本信息

批准号：
18390510
负责人：
WATANABE Makoto
金额：
$ 10.05万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390510/
关键词：
fMRI motor learning oral environment oral function 脳可塑性脳機能

项目摘要

Nine subjects (mean age 28.7) underwent fMRI during chewing gum on the left side of jaw, with and without a resin cap on the lingual region of the maxillary left canine. fMRI acquisition protocol used in the present study has been optimised in our pilot study. fMRI was performed before, immediately after and 30min after applying resin cap. Six out of nine subjects were asked to masticate a wax cube on the left side of jaw in each condition to determine masticatory efficiency. fMRI data were analyzed with SPM2 (Statistical Parametric Mapping 2) to determine differences of brain activity (p=0.001 uncorrected, extent threshold=20voxels).During left side gum chewing, bilateral cerebellar posterior lobe and the proximal part of right supramarginal gyrus were more activated immediately after applying resin cap than before applying it. The activation of cerebellum might show the activity of cerebellum during "motor learning". During left side gum chewing, right cerebellar posterior lobe were less activated 30min after applying resin cap than immediately after applying it. This result might show that the motor learning of left masticatory muscles and the adaptation to left gum chewing with regin cap were achievement.The brain regions showing negative correlation to masticatory efficiency were bilateral postcentral gyrus, left precentral gyrus, right cingulate gyrus, right superior temporal gyrus, right cerebellar posterior lobe and right cerebellar anterior lobe. These findings suggest that right cerebellar posterior and anterior lobe were activated to achieve motor learning of left masticatory muscles to remedy reduced masticatory efficiency immediately after applying resin cap, and were less activated with the improvement of masticatory efficiency and achievement of motor learning 30min after applying resin cap.

9名受试者(平均年龄28.7岁)在左侧颌骨咀嚼口香糖时，在上颌左尖牙舌部有无树脂帽的情况下，进行了fMRI检查。本研究中使用的功能磁共振成像采集方案已在我们的初步研究中进行了优化。分别于戴用树脂帽前、即刻和戴用树脂帽后30min进行fMRI检查。在每种情况下，9名受试者中有6人被要求咀嚼下颌左侧的一个蜡块，以确定咀嚼效率。用SPM2(统计参数图2)对fMRI数据进行分析，以确定脑活动的差异(p=0.001，范围阈值=20体素)。咀嚼左侧口香糖时，双侧小脑后叶和右侧边缘上回近端在戴树脂帽后即刻比戴树脂帽前激活更多。小脑的激活可能反映了“运动学习”过程中小脑的活动。左侧咀嚼口香糖时，右侧小脑后叶在戴树脂帽后30min的激活程度低于戴树脂帽后即刻。与咀嚼效率呈负相关的脑区为双侧中央后回、左侧中央前回、右侧扣带回、右侧颞上回、右侧小脑后叶和右侧小脑前叶。提示右侧小脑后叶和前叶在戴树脂帽后即刻激活左侧咀嚼肌实现运动学习，以弥补咀嚼效率降低，30min后随着咀嚼效率的提高和运动学习成绩的提高而激活较少。