The study of the brain plasticity adapting to the changes of intraoral environment based on the brain molecules
The study of the brain plasticity adapting to the changes of intraoral environment based on the brain molecules
批准号:
20390486
负责人:
WATANABE Makoto
金额:
$9.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
应用正电子发射断层扫描(PET)和脑微透析(MD)技术,观察不同咀嚼对大鼠纹状体多巴胺能系统的影响。雄性F344大鼠分别饲喂固体饲料(S组)和粉末饲料(P组)。这些大鼠在上述条件下饲养至8周龄和60周龄。正电子发射计算机断层扫描结果显示,60周龄时,S组的11C-RAC积累量低于P组。MD研究结果显示,P组8周龄和60周龄时的多巴胺释放量均高于S组。这些结果表明,不同的咀嚼作用在分子水平上对多巴胺能系统产生了影响。
英文摘要
The aim of the present study was to investigate the effects of different mastication on the dopaminergic system in the rat striatum using positron emission tomography (PET)and brain microdialysis (MD). Male F344 rats were fed solid diets (group-S)or powder diets (group-P). These rats were bred reach to 8 and 60 weeks old under the above conditions. As the result of PET study, the accumulation of 11C-RAC at 60 weeks old of group-S was lower than that of group-P. As the result of MD study, dopamine release at 8 and 60 weeks old of group-P was higher than that of group-S. These results suggest that the different mastication influenced on dopaminergic system at the molecular level.
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DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Takahashi Hiroki, Funaki Yoshihito, Tsuboi Akito, Watanabe Makoto, Yamaguchi Satoshi]
通讯作者:
Yamaguchi Satoshi
Quantitative analysis of masticatory activity during unilateral mastication using muscle fMRI.
使用肌肉功能磁共振成像对单侧咀嚼过程中的咀嚼活动进行定量分析。
DOI:
--
发表时间:
2011
期刊:
Oral Diseases
影响因子:
3.8
作者:
[S. Yamaguchi, S. Itoh, Y. Watanabe, A. Tsuboi, Makoto Watanabe, Makoto Watanabe]
通讯作者:
Makoto Watanabe
口腔機能と脳・精神機能の関連
口腔功能与大脑/心理功能之间的关系
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[富澤康彦, 土谷昌広, 他9名, 渡邉誠]
通讯作者:
渡邉誠
DOI:
10.1007/978-4-431-54070-0
发表时间:
2012
期刊:
影响因子:
--
作者:
[K. Sasaki;O. Suzuki;N. Takahashi;P. Stashenko;M. Cambridge]
通讯作者:
K. Sasaki;O. Suzuki;N. Takahashi;P. Stashenko;M. Cambridge
地域高齢者の20歯以上保有と経度認知機能障害の関連:1年の前向きコホート研究
当地老年人牙齿超过20颗与纵向认知功能障碍的关联:一项为期1年的前瞻性队列研究
DOI:
--
发表时间:
2011
期刊:
日本補綴歯科学会雑誌
影响因子:
--
作者:
[西村一将, 大井孝, 高津匡樹, 服部佳功, 坪井明人, 菊池雅彦, 大森芳, 寶澤篤, 辻一郎, 渡邉誠]
通讯作者:
渡邉誠
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