Study on Electronic and Steric Effects of Boron Cluster and Application for Construction of Functional Molecules.

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Carboranes (dicarba-closo-dodecaboranes) are a class of carbon-containing polyhedral boron-cluster compounds having globular shape, remarkable thermal stability and hydrophobic character. In this study, we applied their molecular shape and hydrophobic surface of the molecules to design and synthesis of functional molecules as follows.1. Molecular construction of layered and cyclic molecules with carboranes and benzenes.2. Design and synthesis of mesogenic molecules with carboranes instead of benzenes and cycloalkane.3. Design and synthesis of carborane containing nuclear receptor ligands that interact hydrophobically with receptors.The results achieved in this project (1 and 2) should make it possible to utilize construction of nano-scale chemistry and materials sciences. On the other hands, development of the potent carborane-containing nuclear receptor modulators (retinoid receptor ligands and estrogen receptor ligands) should yield novel candidate therapeutic agents, especially selective receptor modulators. Furthermore, the suitability of the spherical carborane cage for bindiiig to the cavity of receptor should provide a basis for a similar approach to developing novel ligands for other pharmaceutics