EFFICIENT MOLECULAR CONSTRUCTION BY MULTI-COMPONENT COUPLING REACTIONS IN TRANSITION METAL LIGAND FIELDS

1.该研究项目的目标是开发一种新颖的过渡金属介导的反应，以实现建筑复杂分子结构。1997年至2000年财政年度期间在积极研究期间获得的以下研究结果。（1）在1，6-二丁二烯和线性或循环烯烃之间进行高度选择性的交叉偶联，以金属环戊二烯中间体的方式使异原子或终端烯烃存在于有机催化剂中。一个不精确的新多米诺骨牌偶联与双链烯烃。（2）根据烯烃的rhodium催化硅化的机理方面，以及环戊烯的构造，如发现的，四个组成偶联（a）发现了氢硅烷、碳单氧化物和吡酰亚胺;（3）1，6-烯的Rhodium-碳基催化硅化。（4） Rhodium-catalyzed hydrosilylation of 1，6-diynes及其扩展到新的catalytic annelation到C-D260-D2 Fullerene。（5） Rhodium-catalyzed Construction of propargyl alcohols and amines中的异环。（6）铱催化剂迈克尔和硅烯醇醚的aldol反应。（7） Palladium（0）-在电-deficient alkynes和diynes之间催化循环，并将其扩展到新的三聚氰胺循环。（8）新型酮-腈偶联和吡啶醇偶联是由超磁性组织试剂的含义决定的。（9）新的cyclooctatetraene合成从zircona-和titannametalacyclopentadienes开始。

1. The aim of this research project is to develop novel transition metal mediated reactions to construct complex molecular structures. The following research results were obtained in active research conducted from 1997 to 2000 fiscal years.2. (1) Highly selective cross-coupling between 1,6-diynes and linear or cyclic alkenes involving heteroatoms or terminal alkynes in the presence of organoruthenium catalysts by way of metallacyclopentadiene intermediates. Unprecedented new domino couplings of dynes with bicyclic alkenes. (2) Based on the mechanistic aspects of rhodium-catalyzed silylformylation of an alkynes, the construction of cyclopentenones, as well as, four-component coupling of an alkynes, a hydrosilane, carbon monoxide, and pyrrolidine was found. (3) Rhodium-carbonyl catalyzed silylative carbocyclization of 1,6-enynes. (4) Rhodium-catalyzed hydrosilylation of 1,6-diynes and its extension to new catalytic annelation to CィイD260ィエD2 fullerene. (5) Rhodium-catalyzed construction of heterocycles from propargyl alcohols and amines. (6) Iridium-catalyzed Michael and aldol reaction of silylenol ethers. (7) Palladium(0)-catalyzed cyclization between electron-deficient alkynes and diynes and its extension to new triyne cyclization. (8) Novel keto-nitrile coupling and pinacol coupling of dials by means of paramagnetic organization reagents. (9) New cyclooctatetraene synthesis starting from a zircona- and titannametalacyclopentadienes.