EFFICIENT MOLECULAR CONSTRUCTION BY MULTI-COMPONENT COUPLING REACTIONS IN TRANSITION METAL LIGAND FIELDS
过渡金属配体场中多组分偶联反应的高效分子构建
基本信息
- 批准号:09305059
- 负责人:
- 金额:$ 20.29万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (A)
- 财政年份:1997
- 资助国家:日本
- 起止时间:1997 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
1. The aim of this research project is to develop novel transition metal mediated reactions to construct complex molecular structures. The following research results were obtained in active research conducted from 1997 to 2000 fiscal years.2. (1) Highly selective cross-coupling between 1,6-diynes and linear or cyclic alkenes involving heteroatoms or terminal alkynes in the presence of organoruthenium catalysts by way of metallacyclopentadiene intermediates. Unprecedented new domino couplings of dynes with bicyclic alkenes. (2) Based on the mechanistic aspects of rhodium-catalyzed silylformylation of an alkynes, the construction of cyclopentenones, as well as, four-component coupling of an alkynes, a hydrosilane, carbon monoxide, and pyrrolidine was found. (3) Rhodium-carbonyl catalyzed silylative carbocyclization of 1,6-enynes. (4) Rhodium-catalyzed hydrosilylation of 1,6-diynes and its extension to new catalytic annelation to CィイD260ィエD2 fullerene. (5) Rhodium-catalyzed construction of heterocycles from propargyl alcohols and amines. (6) Iridium-catalyzed Michael and aldol reaction of silylenol ethers. (7) Palladium(0)-catalyzed cyclization between electron-deficient alkynes and diynes and its extension to new triyne cyclization. (8) Novel keto-nitrile coupling and pinacol coupling of dials by means of paramagnetic organization reagents. (9) New cyclooctatetraene synthesis starting from a zircona- and titannametalacyclopentadienes.
1.本研究项目的目的是开发新型的过渡金属介导的反应来构建复杂的分子结构。在1997至2000财政年度进行的积极研究中,取得了以下研究成果。(1)1,6-二炔与含杂原子或末端炔的直链或环状烯烃之间的高选择性交叉偶联反应,以金属环戊二烯中间体为催化剂。双环烯烃前所未有的新多米诺骨牌偶联。(2)基于Rh催化的炔硅甲酰化反应的机理,发现了环戊烯酮的结构,以及炔烃、氢硅烷、一氧化碳和吡咯烷的四组分偶联反应。(3)1,6-烯炔的硅烷化碳环化反应。(4)Rh催化的1,6-二炔硅氢加成反应及其延伸到C-ィイD260ィエD2富勒烯的新催化环化反应。(5)铑催化的丙炔醇和胺杂环的构筑。(6)Ir催化的硅酚醚的Michael和Aldol反应。(7)钯(0)催化的缺电子炔烃与二炔的环化反应及其扩展到新的三炔环化反应。(8)利用顺磁性组织试剂实现新型的酮腈偶联和片呐醇偶联。(9)以锆石和钛氨基杂环戊二烯为起始原料合成新的环辛四烯。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yamamoto, Yoshihiko: "Ruthenium-Catalyzed Highly Efficient Intramolecular Olefin Coupling of α, ω-Dienes. Facile and Regioselective Synthesis of exo-Methylenecyclopentanes"J. Org. Chem.. 64(7). 2178-2179 (1999)
Yamamoto, Yoshihiko:“钌催化的 α, ω-二烯的高效分子内烯烃偶联。外型亚甲基环戊烷的简便和区域选择性合成”J. Org. 2178-2179 (1999)。
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Yamamoto, Yoshihiko: "Highly Chemo- and Regioselective [2+2+2] Cross-cyclotrimerization of Unsymmetrical 1,6-Diynes with Terminal Alkynes Catalyzed by Cp*Ru(cod)Cl under Mild Conditions"Chem. Commun.. (7). 549-550 (2000)
Yamamoto, Yoshihiko:“在温和条件下由 Cp*Ru(cod)Cl 催化的不对称 1,6-二炔与末端炔烃的高度化学和区域选择性 [2 2 2] 交叉环三聚”Chem.
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YAMAMOTO, Yoshihiko: "Cp*Ru(cod)Cl-Catalyzed [2 + 2 + 2] Cycloaddition of 1,6-Heptadiynes with Allylic Ethers. A Decisive Role of Coordination to the Ether Oxygen Atom"J. Org. Chem.. 63 (26). 9610-9611 (1999)
YAMAMOTO, Yoshihiko:“Cp*Ru(cod)Cl 催化的 [2 2 2] 1,6-庚二炔与烯丙基醚的环加成。醚氧原子配位的决定性作用”J。
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YAMAMOTO, Yoshihiko: "New Synthetic Potential of Ruthenacyclopentatrienes as Biscarbenoids in Tandem Cyclopropanation of Bicycloalkenes, and Heteroatom-assisted Cyclotrimerization of 1,6-Heptadiynes with Heterocyclic Alkenes"J. Am. Chem. Soc.. 122(in pres
YAMAMOTO,Yoshihiko:“Ruthenacyclopentatrienes 作为 Biscarbenoids 在双环烯烃的串联环丙烷化中的新合成潜力,以及杂原子辅助的 1,6-庚二炔与杂环烯烃的环三聚”J。
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Yamamoto,Yoshihiko: "Fully Substituted Cyclooctatetraenes Assmbled by the [4+4] Cross Coupling of Two Different Diene Units."Chem.Commun.. (16). 1542-1544 (1999)
Yamamoto,Yoshihiko:“通过两个不同二烯单元的 [4 4] 交叉偶联组装完全取代的环辛四烯。”Chem.Commun.(16)。
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{{ truncateString('ITOH Kenji', 18)}}的其他基金
Healthcare Operations Management from Stakeholder Perspectives and Its Cross-National Benchmarking
利益相关者视角下的医疗运营管理及其跨国对标
- 批准号:
23241048 - 财政年份:2011
- 资助金额:
$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Functional Analysis of Auditory Self-Centered Orientation in Brain Virtual Space for Clinical Application
大脑虚拟空间中听觉自我中心定向的功能分析及其临床应用
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20500386 - 财政年份:2008
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$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Developing Risk Management Systems for Patient Safety : Introduction of Patient Views and Fostering Effective Safety and Learning Culture for Healthcare Management
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- 批准号:
18201029 - 财政年份:2006
- 资助金额:
$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of evaluation and diagnostic method on integration and its disorders of mental and language functions by analysis of synchronous oscillations in brain
通过分析大脑同步振荡来开发精神和语言功能整合及其障碍的评估和诊断方法
- 批准号:
15500312 - 财政年份:2003
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$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of gaze interface for disabled people and its extension to low-cost communication tool
残疾人凝视界面的开发及其向低成本通信工具的扩展
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14208040 - 财政年份:2002
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$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Development of evaluation method of mental and language disorders by spatio-temporal analysis of information on brain activities in preconscious process
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13680926 - 财政年份:2001
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$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Development of Highly Efficient Organometallic Catalysis for Short-step Assembly of Complex Moleculer Structures
开发用于复杂分子结构短步组装的高效有机金属催化
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12450360 - 财政年份:2000
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$ 20.29万 - 项目类别:
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11680836 - 财政年份:1999
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Grant-in-Aid for Scientific Research (C)
Work Analysis for White Collar Based on Job-Relevant Knowledge and Work Processes
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10480087 - 财政年份:1998
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$ 20.29万 - 项目类别:
Grant-in-Aid for Scientific Research (B).
Development on extraction method of individuality in spoken language and brain activity information for testing disorders of thought and personality
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09680845 - 财政年份:1997
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Grant-in-Aid for Scientific Research (C)