Detection of parkinsonism causing substances in French West Indies

在法属西印度群岛检测到引起帕金森病的物质

• 批准号: 14406032
• 负责人: OHTA Shigeru
• 金额: $ 8.19万
• 依托单位: HIROSHIMA UNIVERSIlY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14406032/
• 关键词: Parkinson's disease; tetrahvdroisogunoline; Annonaceae family; SH-SY5Y cells; progressive supranuclear palsy; ノルレティキュリン; 国際情報交換; フィリピン:フランス

In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. In the present study, we detected benzylisoquinoline derivatives in the Annonaceae family. These compounds were toxic to SH-SY5Y cells and inhibited mitochondrial respiratory complex I.

在法属西印度群岛的瓜德罗普岛，非典型帕金森症或进行性核上性麻痹的发病率很高，所有调查的患者都曾服用花草茶或番荔枝科热带水果。在本研究中，我们在番荔枝科中检测到了苄基异喹啉衍生物。这些化合物对 SH-SY5Y 细胞有毒并抑制线粒体呼吸复合物 I。

项目成果

K.Okuda, Y.Kotake, S.Ohta: "Determination method of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay"Life Sci.. 70. 2871-2883 (2002)

K.Okuda、Y.Kotake、S.Ohta：“通过放射免疫测定法测定内源性帕金森病预防物质 1-甲基-1,2,3,4-四氢异喹啉”Life Sci.. 70. 2871-2883 (

K.Okuda, Y.Kotake, S.Ohta: "Determination method of 1-methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-preventing substance, by radioimmunoassay."Life Sci.. 70. 2871-2883 (2002)

K.Okuda、Y.Kotake、S.Ohta：“通过放射免疫测定法测定内源性帕金森病预防物质 1-甲基-1,2,3,4-四氢异喹啉。”Life Sci.. 70. 2871-2883

K.Okuda, Y.Kotake, S.Ohta.: "Neuroprotective or neurotoxic activity of 1-methyl 1, 2, 3, 4-tetra-hydroisoquinoline and related compounds"Bioorg.Med.Chem.Lett.. 13. 2853-2855 (2003)

K.Okuda、Y.Kotake、S.Ohta.：“1-甲基 1,2,3,4-四氢异喹啉和相关化合物的神经保护或神经毒性活性”Bioorg.Med.Chem.Lett.. 13. 2853-

A.Storch, et al.: "Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease : studies using heterologous expression systems of the dopamine transporter."Biochem.Pharmacol.. 63. 909-920 (2002)

A.Storch 等人：“与帕金森病相关的异喹啉衍生物的选择性多巴胺能神经毒性：使用多巴胺转运蛋白异源表达系统的研究。”Biochem.Pharmacol.. 63. 909-920 (2002)

K.Okuda, et al.: "Neuroprotective or neurotoxic activity of 1-methyl 1,2,3,4-tetra-hydroisoquinoline and related compounds"Bioorg. Med. Chem. Lett.. 13. 2853-2855 (2003)

K.Okuda 等人：“1-甲基 1,2,3,4-四氢异喹啉及相关化合物的神经保护或神经毒性活性”Bioorg。