Integrated analysis of environmental and genetic factors against Caribbean parkinsonism

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In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. Local inhabitants consume the fruits, and also drink tea made from the leaves.In the present study, we investigated the mechanism of causing the disease and correlation between the din and the fruits.In Annonaceae family, there are some tetrahydroisoquinoline derivatives as alkaloids. These compounds showed neurotoxic effectsIt seems possible that these neurotoxic tetrahydroisoquinoline derivatives are taken into the human body and accumulated in the brain, and they might be rebind to the pathogenesis of the kcal endemic disease.