Integrated analysis of environmental and genetic factors against Caribbean parkinsonism

加勒比帕金森病环境与遗传因素综合分析

• 批准号: 18406004
• 负责人: OHTA Shigeru
• 金额: $ 9.18万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18406004/
• 关键词: parkinsonism; tetrahydroisoquinoline; Annonaceae; neurotoxin; Caribbean islands

In Guadeloupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. Local inhabitants consume the fruits, and also drink tea made from the leaves.In the present study, we investigated the mechanism of causing the disease and correlation between the din and the fruits.In Annonaceae family, there are some tetrahydroisoquinoline derivatives as alkaloids. These compounds showed neurotoxic effectsIt seems possible that these neurotoxic tetrahydroisoquinoline derivatives are taken into the human body and accumulated in the brain, and they might be rebind to the pathogenesis of the kcal endemic disease.

在瓜德罗普岛，法属西印度群岛，非典型帕金森病或进行性核上性麻痹的发病率很高，所有被调查的患者都服用凉茶或番荔枝科的热带水果。当地居民吃这种水果，也喝由叶子制成的茶。在本研究中，我们探讨了该疾病的发病机制以及与果实的相关性。在番荔枝科中，有一些四氢异喹啉衍生物作为生物碱。这些具有神经毒性的四氢异喹啉衍生物可能被人体吸收并在脑内积累，并可能与土地病的发病机制有关。

项目成果

Concentration dependence of the mechanisms of tributyltin-induced apoptosis

• DOI: 10.1093/toxsci/kfm039
• 发表时间: 2007-06-01
• 期刊: TOXICOLOGICAL SCIENCES
• 影响因子: 3.8
• 作者: Nakatsu, Yusuke;Kotake, Yaichiro;Ohta, Shigeru
• 通讯作者: Ohta, Shigeru

Parkinsonism-causing toxins enhance gap junction in astrocytes.

引起帕金森病的毒素增强星形胶质细胞的间隙连接。

• 发表时间: 2007
• 作者: Kawasaki;et. al.,
• 通讯作者: et. al.,

Cytotoxicity of 17 tetrahydroisoquinoline derivatives in SH-SY5Y human neuroblastoma cells is related to mitochondrial NADH-ubiquinone oxidoreductase inhibition.

17 种四氢异喹啉衍生物在 SH-SY5Y 人神经母细胞瘤细胞中的细胞毒性与线粒体 NADH-泛醌氧化还原酶抑制有关。

• 发表时间: 2007
• 期刊: Neurotoxicology 28・1
• 作者: Shinobu Honzawa;et al.;Kotake Y. et al.
• 通讯作者: Kotake Y. et al.

環境化学物質のタンパク結合を介した作用とパーキンソン病

蛋白质结合介导的环境化学物质与帕金森病的影响

• 发表时间: 2008
• 作者: 古武弥一郎;幸田龍紀;太田茂
• 通讯作者: 太田茂

P糖タンパク欠損マウスにおけるパーキンソン病発症候補物質3',4'DHBnTIQの影響

3,4DHBnTIQ（一种帕金森病候选物质）对 P-糖蛋白缺陷小鼠的影响

• 发表时间: 2008
• 作者: 山下智香;ら
• 通讯作者: ら