Early markers of Parkinson's disease

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The significant decrease in 1MeTIQ content in the brain of PD patients may be due to an increase in the rate of degradation of 1MeTIQ and/or a decrease of 1MeTIQ biosynthesis. Our results support the idea that endogenous and exogenous inducers of parkinsonism do inhibit the biosynthesis of 1MeTIQ, which bas a parkinsonism-preventive effect via an unknown mechanism. Our findings are also consistent with a report that the 1MeTIQ content is decreased in MPTP-treated C57BL/6 mouse brain. Deprenyl can reduce the content of 1BnTIQ (a parkinsonism-including compound) and increase the content of 1MeTIQ (a parkinsonism-protective compound). The balance of 1BnTIQ content to 1MeTIQ content may be very important especially striatum and substantia nigra of PD patients. Development of the anti-parkinsonian drug for above mentioned mechanism is desirable.