Elucidation of the cause of Caribbean parkinsonism and prevention in other area
加勒比帕金森病的病因阐明及其他领域的预防
基本信息
- 批准号:16406004
- 负责人:
- 金额:$ 8.32万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2004
- 资助国家:日本
- 起止时间:2004 至 2005
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
In Guaderoupe, the French West Indies, there is a high incidence of atypical parkinsonism or progressive supranuclear palsy, and all of the investigated patients had taken herbal tea or tropical fruits of the Annonaceae family. Local inhabitants consume the fruits, and also drink tea made from the leaves. In the present study, we used liquid chromatography-tandem mass spectrometry (LC/MS/MS) with multiple reaction monitoring (MRM) to detect low-molecular-weight neurotoxic benzylisoquinoline derivatives in the Annonaceae family. We detected reticuline and N-methylcoculaurine in every Annona muricata sample examined, except for pulp and seed. They were not detected in sweetsop fruits. Norreticuline was not detected in any sample. These three compounds were toxic to SH-SY5Y neuroblastoma cells and inhibited mitochondrial respiratory complex I. It is possible that uptake of the benzylisoquinoline derivatives reticuline and N-methylcoculaurine and their accumulation in the brain may be related to the pathogenesis of the local endemic disease.
在法属西印度群岛的瓜德鲁普,非典型帕金森症或进行性核上性麻痹的发病率很高,所有被调查的患者都服用了草药茶或番荔枝科的热带水果。当地居民食用水果,也喝叶子制成的茶。在本研究中,我们使用带有多反应监测(MRM)的液相色谱-串联质谱(LC/MS/MS)来检测番荔枝科中的低分子量神经毒性苄基异喹啉衍生物。我们检测到牛心果碱和N-甲基coculaurine在每个番荔枝样品检查,除了果肉和种子。在番荔枝果实中未检出。在所有样品中均未检出去甲牛心果碱。这三种化合物对SH-SY 5 Y神经母细胞瘤细胞具有毒性,并抑制线粒体呼吸复合物I。这是可能的苄基异喹啉衍生物牛心果碱和N-甲基coculaurine的摄取和它们在大脑中的积累可能与当地地方病的发病机制。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Glutamate excitotoxicity is involved in cell death caused by tributyltin in cultured rat cortical neurons
- DOI:10.1093/toxsci/kfj007
- 发表时间:2006-01-01
- 期刊:
- 影响因子:3.8
- 作者:Nakatsu, Y;Kotake, Y;Ohta, S
- 通讯作者:Ohta, S
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OHTA Shigeru其他文献
Does near-infrared spectroscopy detect arterial or venous blood flow ?
近红外光谱可以检测动脉或静脉血流吗?
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
NAKAMOTO Hiroshi;OHTA Shigeru - 通讯作者:
OHTA Shigeru
Analysis of Blood flow Changes of Portal Vein by Near Infrared Spectroscopy
近红外光谱分析门静脉血流变化
- DOI:
- 发表时间:
2007 - 期刊:
- 影响因子:0
- 作者:
NAKAMOTO Hiroshi;IWAMURA Yoshiaki;KOUNO Takayuki;SHINAGAWA Yoshimitsu;OHTA Shigeru - 通讯作者:
OHTA Shigeru
OHTA Shigeru的其他文献
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{{ truncateString('OHTA Shigeru', 18)}}的其他基金
Toxicities and pharmacokinetics of new chemical structures of designer drugs, and their prediction in humans
设计药物新化学结构的毒性和药代动力学及其对人体的预测
- 批准号:
18H03066 - 财政年份:2018
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Prediction of interindividual differences of drug metabolism and pharmacokinetics using chimeric mice with humanized liver
利用人源化肝脏嵌合小鼠预测药物代谢和药代动力学的个体差异
- 批准号:
23659053 - 财政年份:2011
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Pathogenetic mechanism of sporadic Parkinson's disease based on familial Parkinson's disease
基于家族性帕金森病的散发性帕金森病发病机制
- 批准号:
20390040 - 财政年份:2008
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Drug development using novel animal model based on the pathogenesis of Parkinson' s disease-related disorders
使用基于帕金森病相关疾病发病机制的新型动物模型进行药物开发
- 批准号:
20406005 - 财政年份:2008
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of anti-Parkinson's disease drugs using P-glycoprotein knockout mice heated with endogenous neurotoxin.
使用内源性神经毒素加热的 P-糖蛋白敲除小鼠开发抗帕金森病药物。
- 批准号:
18390037 - 财政年份:2006
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Integrated analysis of environmental and genetic factors against Caribbean parkinsonism
加勒比帕金森病环境与遗传因素综合分析
- 批准号:
18406004 - 财政年份:2006
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
A Study on Blood Flow Changes by Near Infrared Spectroscopy at Organ Surfaces for a Human Health Index
近红外光谱法研究器官表面血流变化以评估人类健康指数
- 批准号:
17300188 - 财政年份:2005
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Parkinsonism-inducing mechanism by endogenous multifunctional neurotoxins in the brain
脑内源性多功能神经毒素诱发帕金森病的机制
- 批准号:
16390041 - 财政年份:2004
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Detection of parkinsonism causing substances in French West Indies
在法属西印度群岛检测到引起帕金森病的物质
- 批准号:
14406032 - 财政年份:2002
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
STUDY ON THE EXPRESSION OF ESTROGEN RECEPTORS IN MALIGNANT RHABDOID TUMOR
恶性横纹肌瘤中雌激素受体表达的研究
- 批准号:
14570741 - 财政年份:2002
- 资助金额:
$ 8.32万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
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Development and Translation Mass Spectrometry Methods to Determine BioMarkers for Parkinson's Disease and Comorbidities
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