A Study on development of realtime system for diagnosis of regional elasticity of myocardium and arterial wall using ultrasound

超声实时诊断心肌及动脉壁局部弹性系统的研制

• 批准号: 06555113
• 负责人: KANAI Hiroshi
• 金额: $ 2.56万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06555113/
• 关键词: atherosclerosis; local elastic characteristics; pulse wave velocity; ultrasonic diagnosis; non-invasive diagnosis; ultrasonic Doppler method; small vibration measurements; diseases of circulatory system; 心筋症; 局所的壁弾性率

In this research, we have developed a new system to accurately measure small vibration signal on the heart wall and arterial wall. By this method, small vibrations of the heart wall with small amplitudes less than 100 mum on the motion resulting from a heartbeat with large amplitude of 10 mm can be successfully detected with sufficient reproducibility in the frequency range up to several hundred Hertz continuously for periods of about ten heartbeats. The resultant small vibration is analyzed not only in the time domain but also in the frequency domain. As confirmed by the preliminary experiments herein reported, the new method offers potential for research in acoustical diagnosis of heart disease.On the other hand, this system is also applicable to the measurement of local pulse wave velosity, which is an index of the hardness in the range of several millimeters on the aortic wall. In the standard method, the pulse wave velocity (PWV) is obtained from the difference in arrival time of … More pressure waves propagating from the carotid artery to the femoral artery. In this method, the measurable points are limited to those where the aorta exists near the skin surface and the distance between such points is considerable long, i. e., several hundred millimeters. It is important for early diagnosis, however, to measure the local hardness of the surface of the arterial wall. To increase the spatial resolution, it is necessary to measure vibrations due to pulse waves with frequency components up to about 50 Hz.The developed system is also applied to measurement of local PWV by simultaneously measuring small vibrations at two points on the surface of the aortic wall. By the developed method, high spatial resolution, which is necessary in the evaluation of local hardness, is attained. By comparing the static experiments and dynamic experiments using a silicon tube, it is confirmed that the local hardness (Young's modulus) of the vessel wall is also evaluated with high spatial resolution. The local elasticity (Young's modulus) is also evaluated for each measurement point. Thus, the developed system will be effective also for local evaluation of the hardness on the aortic wall. Less

在本研究中，我们开发了一种新的系统，以准确地测量心脏壁和动脉壁上的微小振动信号。通过这种方法，在由具有10 mm的大振幅的心跳引起的运动中具有小于100 μ m的小振幅的心壁的小振动可以在高达几百赫兹的频率范围内连续地以大约十次心跳的周期以足够的再现性被成功地检测。由此产生的小振动不仅在时域中，而且在频域中进行了分析。本文报道的初步实验证实，新的方法提供了潜在的心脏疾病的声学诊断的研究。另一方面，该系统也适用于局部脉搏波速度的测量，这是在主动脉壁上的硬度在几毫米的范围内的指标。在标准方法中，脉搏波速度（PWV）是从以下各项的到达时间差获得的： ...更多信息 压力波从颈动脉传播到股动脉。在该方法中，可测量点仅限于主动脉存在于皮肤表面附近的那些点，并且这些点之间的距离相当长，即。例如，几百毫米然而，测量动脉壁表面的局部硬度对于早期诊断是重要的。为了提高空间分辨率，有必要测量振动，由于脉搏波的频率分量高达约50 Hz。所开发的系统也适用于测量局部PWV同时测量小振动在主动脉壁的表面上的两个点。通过所开发的方法，高的空间分辨率，这是必要的局部硬度的评价，是实现。通过比较静态实验和动态实验，使用硅管，它被证实，局部硬度（杨氏模量）的血管壁也具有高的空间分辨率进行评估。还针对每个测量点评估局部弹性（杨氏模量）。因此，所开发的系统也将是有效的主动脉壁上的硬度的局部评价。少

项目成果

H.Kanai,T.Hori,N.Chubachi,T.Ono: "Delayed Block Transfer Function and its Application to Accurate Estimation of Transfer Function" IEEE Transactions on Signal Processing. 41. 1669-1684 (1994)

H.Kanai、T.Hori、N.Chubachi、T.Ono：“延迟块传输函数及其在传输函数精确估计中的应用”IEEE 信号处理汇刊。

H.Kanai,k.kawabe,M.Takano,R.Murata,N.Chubachi,Y.Koiwa: "New Method dor Evaluating Local Pulse Wave Velocity by Measuring Vibrations on Arterial Wall" IEE Electronics Letters. 30. 534-536 (1994)

H.Kanai、k.kawabe、M.Takano、R.Murata、N.Chubachi、Y.Koiwa：“通过测量动脉壁振动评估局部脉搏波速度的新方法”IEE 电子通讯。

高野正彦,金井 浩,中鉢憲賢,小岩喜郎,手塚文明,高橋光浩: "動脈硬化の局所診断のための血管壁上微小振動の計測と解析" 日本音響学会誌. 51. 174-181 (1995)

Masahiko Takano、Hiroshi Kanai、Kenken Chubachi、Yoshiro Koiwa、Fumiaki Tezuka、Mitsuhiro Takahashi：“用于动脉硬化局部诊断的血管壁微小振动的测量和分析”日本声学学会杂志 51. 174-181（1995 年）。 ) )

Hiroshi Kanai, Muhun Park, and Noriyoshi Chubachi: "In vivo measurement of frequency characteristics of phase velocity of bone with bending vibration" IEE Electronics Letters. vol.31, no.23. 1969-1971 (1995)

Hiroshi Kanai、Muhun Park 和 Noriyoshi Chubachi：“弯曲振动下骨相速度频率特性的体内测量”IEE 电子通讯。

Tomohisa Kimura,Hiroshi Kanai,and Noriyoshi Chubachi:"“High-Resolution Determination of Transit Time of Ultrasound in a Thin Layer in Pulse-Echo Method,"" IEICE Transactions on Fundamentals of Electronics,Communications and Computer Sciences,. E78. 1677-1

Tomohisa Kimura、Hiroshi Kanai 和 Noriyoshi Chubachi：“脉冲回波法中薄层中超声波传播时间的高分辨率测定”，IEICE 电子、通信和计算机科学基础汇刊，E78.1677- 1