Development of the ultrasonic quantitative diagnostic system using acoustic characteristic change of a liver tissue

本研究提出了利用声学和生物学特征对肝硬化人肝组织进行组织表征的方法。第一种方法是回波幅度的统计处理技术。采用超声诊断设备对8例体外肝硬化患者的射频回波信号进行了采集。我们的处理技术提取了不服从瑞利分布的回波信息。利用提取的200张断层扫描回波信息构建的肝脏三维图像中，可以清晰地看到许多薄结构。第二种方法是使用染色的组织学组织切片确认纤维组织结构的细节。从每个染色的石蜡切片中提取特定的颜色成分，并根据提取的颜色信息构建三维纤维结构。通过统计处理提取的回波信息和衰减特别大的区域，可以清楚地确定纤维化组织的体积结构。

This research presents tissue characterization method for cirrhotic human liver tissue using acoustical and biobgical characteristics. The first approach is a statistical processing technique of echo amplitude. RF echo signals from 8 in vitro samples of human cirrhotic liver were obtained using ultrasonic(US) diagnostic equipment. Our processing technique extracts the echo information that does not obey a Rayleigh distribution. In the 3D image of each liver which were constructed with extracted echo information from 200 tomograms, many thin structures can be seen clearly. The second approach is acknowledgement of the detail of fiber tissue structure using stained histological tissue sections. A particular color component was extracted from each stained paraffin section, and the 3D fiber structure constructed from extracted color information. The volumetric structures of fibrotic tissues can be confirmed clearly, and they agreed with the extracted echo information using statistical processing and the regions which have the especially large attenuation.