Quantitative Diagnosis of Liver Cirrhosis using Ultrasonic Image

超声图像定量诊断肝硬化

• 批准号: 11650417
• 负责人: HACHIYA Hiroyuki
• 金额: $ 2.43万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11650417/
• 关键词: medical ultrasound; quantitative diagnosis; liver cirrhosis; tissue characterization; probability density function; Rayleigh distribution; 3D image; 医用超音波; 生体組織

To realize quantitative diagnosis of liver cirrhosis, we analyze the probability density function (PDF) using RF echo signal and B-mode images of normal and cirrhotic livers, and compare both results to examine the validity of the RF echo signal.We present the statistical characteristics of the echo envelope of normal and cirrhotic livers, and the technique to extract information of the scatterer distribution from the normal and cirrhotic liver RF echo signal using constant false alarm rate (CFAR) processing. We found the quantitative relationship between the extracted scatterer distribution and the stage of liver cirrhosis.The cirrhotic liver has many fibrotic tissue structures known as nodule structures. Understanding this characteristic in diseased tissue is important for quantitative diagnosis. We present a technique to extract quantitative three-dimensional information from a cirrhotic liver. Consecutive two-dimensional images acquired by fan like scanning were processed using constant false alarm rate (CFAR). The 2D processed images are accumulated to obtain 3D information. The nodular structure is clear in the constructed images.It is found that the proposed technique is valid for the quantitative diagnosis of liver cirrhosis.

为了实现对肝硬变的定量诊断，我们对正常和肝硬变的射频回波信号和B超图像进行概率密度函数(PDF)分析，并将两者的结果进行比较，以检验射频回波信号的有效性。给出了正常和肝硬变的回波包络的统计特征，以及利用恒虚警率(CFAR)处理从正常和肝硬变的射频回波信号中提取散射体分布信息的方法。我们发现了所提取的散射体分布与肝硬变分期之间的定量关系。了解病变组织的这一特征对于定量诊断很重要。我们提出了一种从肝硬变中提取定量三维信息的技术。利用恒虚警率(CFAR)对扇形扫描获得的连续二维图像进行处理。对2D处理后的图像进行累加以获得3D信息。在构建的图像中，结节结构清晰。结果表明，该技术对肝硬变的定量诊断是有效的。

项目成果

T.Yamaguchi: "Estimation of characteristics of echo envelope using RF echo signal from the liver"Japanese Journal of Applied Physics.. 40. (2001)

T.Yamaguchi：“使用来自肝脏的 RF 回波信号估计回波包络的特征”日本应用物理学杂志.. 40. (2001)

T.Yamaguchi: "The quantitative diagnosis of liver cirrhosis using CFAR processing of the ultrasonic volumetric images (invited)"The Seventh Western Pacific Regional Acoustics Conference. 2. 1285-1288 (2000)

T.Yamaguchi：“利用超声体积图像的CFAR处理对肝硬化进行定量诊断（特邀）”第七届西太平洋区域声学会议。

T. Hara: "New Modeling Technique for the Scatterer Distribution Change"Japanese Journal of Applied Physics. (未定). (2000)

T. Hara：“散射体分布变化的新建模技术”，日本应用物理学杂志（待定）。

Hideaki Shigemoto: "Measurement of acoustic property distributions of diseased heart and liver tissues"Japanese Journal of Applied Physics. 40(掲載決定). (2001)

Hideaki Shigemoto：“患病心脏和肝脏组织的声学特性分布的测量”，《日本应用物理学杂志》40（出版）。

T.Yamaguchi: "The Extraction of Quantitative 3D Information from the Ultrasonic Volumetric Images of Cirrhotic Liver"Jpn.J.Appl.Phys.. 39 (5B). 3266-3269 (2000)

T.Yamaguchi：“从肝硬化肝脏超声体积图像中提取定量 3D 信息”Jpn.J.Appl.Phys. 39 (5​​B)。