Quantitative Diagnosis for Liver and Heart Desease Using Ultrasonic RF Images

使用超声波射频图像定量诊断肝脏和心脏病

• 批准号: 13650455
• 负责人: HACHIYA Hiroyuki
• 金额: $ 2.3万
• 依托单位: CHIBA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13650455/
• 关键词: medical ultrasound; quantitative diagnosis; liver cirrhosis; tissue characterization; probability density function; Rayleigh distribution; 3D image; chronic hepatitis; 振幅特性; レイリー分布

The purpose of this study is to examine the relationship between physical change and echo signal information of tissues with the disease and develop the quantitative diagnosis method of heart and liver diseases. We measured the acoustic characteristics of tissues of heart failure, liver cirrhosis and chronic hepatitis. The acoustic characteristics were different in normal tissue and diseased tissue, and the fiber structure has the characteristic features of sound velocity and attenuation distribution. The analysis of amplitude distribution of RF echo signal was carried out using the digital ultrasonic diagnostic equipment. The probability density functions of echo signal amplitude from the fibrotic tissue are different from the Rayleigh distribution, while the probability density functions of echo signal amplitude from the normal tissue agree approximately with the Rayleigh distribution. It was confirmed that signal amplitude probability density gradually changed from the Rayleigh distribution, as the stage of liver disease progress from the normal to liver cirrhosis. Then we tried to the extract of three-dimensional structure of fibrotic tissues using the statistically processing technique for non-Rayleigh component in echo signal. The extracted information as a non-Rayleigh component increases with the progress of the disease. It seems that the extracted three-dimensional structure corresponds to the fibrous tissues structure.It is found that the RF echo information reflects the change of the tissue characteristics quantitatively. The proposed technique is valid for the quantitative diagnosis of liver and heart diseases.

本研究的目的是探讨组织的物理变化与疾病回声信号信息之间的关系，建立心、肝疾病的定量诊断方法。我们测量了心力衰竭、肝硬化和慢性肝炎组织的声学特性。正常组织和病变组织的声学特性不同，纤维结构具有声速和衰减分布的特征。利用数字化超声诊断仪对射频回波信号的幅度分布进行了分析。纤维化组织的回波信号幅度的概率密度函数不同于瑞利分布，而正常组织的回波信号幅度的概率密度函数近似符合瑞利分布。证实了随着肝病从正常到肝硬化的进展，信号幅度概率密度从瑞利分布逐渐改变。然后尝试利用回波信号中非瑞利分量的统计处理技术提取纤维化组织的三维结构。作为非瑞利分量的提取信息随着疾病的进展而增加。提取的三维结构似乎与纤维组织结构相对应，射频回波信息定量地反映了组织特征的变化。该方法对肝脏和心脏疾病的定量诊断是有效的。

项目成果

山口 匡: "超音波断層画像を用いた硬変肝組織散乱体分布情報の検討"電子情報通信学会論文誌. J84-A 12. 1475-1483 (2003)

Tadashi Yamaguchi：“使用超声断层扫描图像检查肝硬化肝组织中的散射体分布信息”，电子、信息和通信工程师学会汇刊 J84-A 12. 1475-1483 (2003)。

Hideaki Shigemoto: "Measurement of Acoustic Property Distributions of the Diseased Heart and liver tissues"Japanese Journal of Applied Physics. 40. 3811-3814 (2001)

Hideaki Shigemoto：“患病心脏和肝脏组织的声学特性分布的测量”日本应用物理学杂志。

山口 匡: "超音波断層画像を用いた硬変肝組織散乱体分布情報の検討"電子情報通信学会論文誌. J84-A12. 1475-1483 (2002)

Tadashi Yamaguchi：“使用超声断层扫描图像检查肝硬化肝脏组织中的散射体分布信息”，电子、信息和通信工程师学会汇刊 J84-A12 (2002)。

Tadashi Yamaguchi: "Extraction of the Spatial Correlation of Statistics Information in the Ultrasonic Echo from Diseased Liver"Japanese Journal of Applied Physics. 41. 3585-3589 (2002)

Tadashi Yamaguchi：“从患病肝脏的超声回波中提取统计信息的空间相关性”日本应用物理学杂志。

Hideaki Shigemoto: "Measurement of acoustic property distributions of diseased heart and liver tissues"Japanese Journal of Applied Physics. 40. 3912-3917 (2001)

Hideaki Shigemoto：“患病心脏和肝脏组织的声学特性分布的测量”日本应用物理学杂志。