Clarification of relation between acoustic characteristic and ultrasonic image of biological tissue

阐明生物组织的声学特性与超声图像之间的关系

• 批准号: 17500326
• 负责人: HACHIYA Hiroyuki
• 金额: $ 2.24万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17500326/
• 关键词: Tissue Characterization; Quantitative diagnosis; Ultrasonic diagnosis; Echo filter; Probability density function; 超音波; 医用画像; 肝硬変

In the clinical diagnosis using ultrasonic diagnostic equipment, it is difficult to understand the tissue structure by using only two dimensional plane information of ultrasonic B-mode image. In this research, we tried to understanding the relationship between the tissue change that caused by some disease such as fibrosis and the characteristics change (of echo signal for ultrasonic images).The three dimensional echo filter was disigned to improve the accuracy when data is collected with ultrasonic diagnostic equipment. The resolution of the ultrasonic beam which was irradiated to human body is differs respectively in depth, the azimuth, and the direction of the elevation. Then, the measurement accuracy for every has been improved by deciding the parameter of the filter based on resolution in the direction of three dimensions.Moreover, we proposed signal analyzing methods for quantitative diagnosis. Our methods paid attention to the relation between the scatter density and the characteristics of echo signal in the living human body. Quantifying the feature of a different element in an inhomogeneous medium (diseased tissue) became possible by combining some analytical methods.In addition, the system to measure the acoustic characteristic of the biological tissue high-speed and in a high density was restructured. As a result of measurement of eight liver specimens, the measurement speed and the range that can be measured quadrupled compared with the previous system. As a result, the error margin because of the change in the measurement environment decreased, and a highly accurate measurement became possible.

在临床使用超声诊断设备进行诊断时，仅利用超声b型图像的二维平面信息很难了解组织结构。在本研究中，我们试图了解某些疾病（如纤维化）引起的组织变化与超声图像回波信号特征变化之间的关系。为了提高超声诊断设备采集数据的准确性，设计了三维回波滤波器。超声波束辐照人体时，其分辨率在深度、方位和仰角方向上分别存在差异。然后，根据三维方向上的分辨率来确定滤波器的参数，提高了每一个的测量精度。此外，我们还提出了定量诊断的信号分析方法。我们的方法关注的是人体散射密度与回波信号特性之间的关系。通过结合一些分析方法，可以在不均匀的培养基（病变组织）中量化不同元素的特征。此外，重构了高速高密度测量生物组织声学特性的系统。通过对8个肝脏标本的测量，使测量速度和测量范围比原有系统提高了4倍。结果，由于测量环境的变化而导致的误差范围减小，并且高度精确的测量成为可能。

项目成果

A piot approach for quantitative assessment of liver fibrosis using ultrasound : preliminary result in 79 cases

超声定量评估肝纤维化的初步方法：79例初步结果

• 发表时间: 2006
• 期刊: Journal of Hepatology 44・1
• 作者: Tadashi Yamaguchi;Hiroyuki Hachiya;et al.;Tadashi Yamaguchi;Hiroyuki Yamada
• 通讯作者: Hiroyuki Yamada

Evaluation of Ultrasonic Fiber Structure Extraction Technique Using Autopsy Specimens of Liver

• DOI: 10.1143/jjap.44.4615
• 发表时间: 2005-06
• 期刊: Japanese Journal of Applied Physics
• 影响因子: 1.5
• 作者: Tadashi Yamaguchi;Kazuki Hirai;H. Yamada;M. Ebara;H. Hachiya

Measurement Method of Thrombus Flux Using Transesophageal Echocardiography

经食管超声心动图的血栓流量测量方法

• 发表时间: 2006
• 期刊: Japanese Journal of Applied Physics Vol. 45 No. 5B
• 作者: Tadashi Yamaguchi;Hiroyuki Hachiya;et al.
• 通讯作者: et al.