Neurobiology of hydra primitive nervous system

(1)水螅弥漫性神经系统的结构（神经解剖学）水螅体内多肽信号分子的大规模筛选，鉴定出许多新的多肽，并制备了针对每种多肽的抗体。利用这些抗体，我们对水螅神经系统进行了化学解剖。(2)水螅的扩散神经系统功能（神经生理学、行为生理学）我们证明了水螅的简单神经系统具有与高等动物中枢神经系统相当的能力。我们检验了我们的假设，水螅的神经环是高级神经系统的中枢神经系统的起源，我们确定了神经环的一个功能，即协调同时的触手运动，皱褶…(3)水螅弥漫性神经系统的形成（发育神经生物学）我们鉴定了两类肽，一类是激活水螅神经分化的Hym355，另一类是抑制水螅神经分化的LPW肽家族。Hym355是神经肽，而LPW家族是上皮肽。这些肽被证明对神经干细胞、间质细胞有影响。

(1)Structure of the diffuse nervous system of hydra (neuroanatomy)Large scale screening of peptide signal molecules in hydra, many novel peptides were identified We produced antibodies against every peptides. Using these antibodies, we did chemical anatomy of hydra nervous system.(2)Function of the diffuse nervous system of hydra (neurophysiology, behaviorall physidogy)We demonstrated that the simple nervous system of hydra had abilities comparable to central nervous system of the higher animals. We examined our hypothesis nerve ring in hydra is the originn of the central nervous system of higher nervous system We identified a function of the nerve ring, which was the coordination of the simulutanous tentacle movement, crumpling..(3)Formation of the diffuse nmous system of hydra (developmental neurobiology)We identified two types of peptides, one is Hym355 activating nerve differentiation of hydra, and the other is LPW peptide family inhibiting nerve differentiation of hydra. Hym355 was a neuropeptide, but LPW family was epitheliopeptides. These peptides were demonstrated to affect on the nerve stem cells, interstitial celsl.