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A study of stimulus conditions of repetitive transcranial magnetic stimulation using neurophysiological neuroimaging techniques

利用神经生理学神经影像技术研究重复经颅磁刺激的刺激条件

基本信息

批准号：
15591220
负责人：
UKAI Satoshi
金额：
$ 2.3万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

The aim of this study was to examine the optimum stimulus conditions and therapeutic mechanisms of rTMS (repetitive transcranial magnetic stimulation) therapy using neurophysiological techniques. The main results of this study are as follows.1.Mechanisms of therapeutic effects of rTMS investigated by HFOs (high frequency oscillations)HFOs of SEPs (somatosensory evoked potentials) in 7 healthy human subjects were recorded before and after slow rTMS on the primary sensory area (0.5 Hz, 50 pulses, 80% motor threshold). The subjects showed significant increase of the amplitude and the power of HFOs after the real rTMS, while they did not show it after the sham rTMS. These results suggest that the slow rTMS might directly increase the activity of the GABAergic inhibitory interneurons in the cortex and suppress cortical excitability through these inhibitory interneurons, causing the therapeutic effects. They also indicate that HFOs are one of the candidates of objective indicators to find th … More e optimum stimulus conditions for the rTMS therapies.2.Examination of neural activations in the dorsolateral prefrontal cortex (DLPFC) in the Stroop task in schizophrenic patients using a spatially filtered MEG analysis.We estimated neural activations in the Stroop task in nearly real time for schizophrenic patients with/without auditory hallucinations. One hundred unaveraged MEG signals during the incongruent stimulus responses were analyzed with a time window of 200 ms in steps of 50 ms. In the 25-60 Hz band, cortical regions that showed significant current source density (CSD) changes were examined for each time window. Transient neural activations in the DLPFC, corresponding to significantly decreased CSD, were bilateral with left-side dominancy for the normal controls, left-lateralized for the non-hallucinators and right-lateralized for the hallucinators, suggesting that the dysfunction in the left DLPFC was related to auditory hallucinations. It is suggested that our neuroimaging techniques are useful for examining the dynamics of the brain neural network in relation with clinical features of patients and effects of the rTMS therapies. Less

本研究的目的是研究最佳的刺激条件和治疗机制的重复经颅磁刺激（rTMS）治疗使用神经生理技术。本研究的主要结果如下：1.高频振荡（HFO）研究rTMS的治疗机制7名健康人在初级感觉区（0.5Hz，50脉冲，80%运动阈值）进行慢速rTMS前后记录了体感诱发电位（SEPs）的HFO。受试者在真实的rTMS后HFO的振幅和功率显著增加，而在假rTMS后没有显示。提示慢rTMS可能通过直接增加皮层GABA能抑制性中间神经元的活性，并通过这些抑制性中间神经元抑制皮层兴奋性而发挥治疗作用。HFOs也是一个可以用来评价HFOs的客观指标 ...更多信息 2.应用空间滤波脑磁图分析技术检测精神分裂症患者Stroop任务中背外侧前额叶皮层（DLPFC）神经元的激活情况我们估计了有/无幻听的精神分裂症患者Stroop任务中接近真实的时间的神经元激活情况。100个非平均的MEG信号在不一致的刺激反应进行了分析，在25-60 Hz频段，显示显着的电流源密度（CSD）的变化，在每个时间窗口的时间窗口为200毫秒的步骤。DLPFC的短暂神经激活，对应于显着降低CSD，是双边的左侧优势的正常对照组，左侧偏侧的非幻觉和右侧偏侧的幻觉，这表明在左侧DLPFC的功能障碍与幻听。这表明，我们的神经影像学技术是有用的检查动态的脑神经网络与患者的临床特征和效果的rTMS治疗。少