Strategy of gene therapy against ovarian cancer by using endostatin

内皮抑素基因治疗卵巢癌的策略

• 批准号: 15591784
• 负责人: YONEYAMA Koichi
• 金额: $ 1.86万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591784/
• 关键词: ovarian cancer; endostatin; VEGF; angiogenesis; 血管新生抑制因子

In this study, we investigated the serum endostatin and VEGF(vascular endothelial growth factor) levels of the patients with various ovarian tumors. [MATERIALS AND METHODS]To evaluate the serum levels of endostatain, blood samples were obtained from the fourteen patients with ovarian cancers, four normal volunteers. And to evaluate the serum levels of VEGF, blood samples were obtained from the twenty four patients with ovarian cancers, twenty three patients with benign ovarian tumors and nine normal volunteers. Informed concents were obtained by all pearsons. [RESULTS]The serum endostatin level was 94.9±36.4 ng/mL in the patients with ovarian cancers, 63.01±17.1ng/mL in the normal volunteers. The serum VEGF level was 664.3 pg/mL in the patients with ovarian cancers, 307.4 pg/mL in the patients with benign ovarian tumors, 311.2 pg/mLn the normal volunteers. The serum endostatin and VEGF levels in the patients with ovarian cancers were clearly higher than normal volunteers (p<0.05). [CONCLUSIONS]The serum endostatin and VEGF levels can be useful marker for the ovarian cancer screening.

在本研究中，我们研究了各种卵巢肿瘤患者血清内皮抑素和VEGF（血管内皮生长因子）水平。[材料与方法]收集14例卵巢癌患者和4例正常人血清，测定血清内皮抑素水平。检测24例卵巢癌患者、23例卵巢良性肿瘤患者和9例正常人血清VEGF水平。所有培生公司都获得了知情同意。[结果]卵巢癌患者血清内皮抑素水平为94.9± 36.4ng/mL，正常人为63.01±17.1ng/mL;卵巢癌患者血清VEGF水平为664.3pg/mL，卵巢良性肿瘤患者血清VEGF水平为307.4pg/mL，正常人血清VEGF水平为311.2pg/mL。卵巢癌患者血清内皮抑素和VEGF水平明显高于正常对照组（P<0.05）。[结论]血清内皮抑素和VEGF水平可作为卵巢癌筛查的有用指标。

项目成果

Okino K, Nagai H, Hatta M, Nagahata T, Yoneyama K, et al.: "Up-regulation and overproduction of DVL-1,the human counterpart of the Drosophila dishevelled gene, in cervical squamous cell carcinoma."Oncol Rep.. 10・5. 1219-1223 (2003)

Okino K、Nagai H、Hatta M、Nagahata T、Yoneyama K 等人：“DVL-1（果蝇蓬乱基因的人类对应物）在宫颈鳞状细胞癌中的上调和过量产生。”Oncol Rep.. 10・5。1219-1223（2003）

A case of malignant lymphoma (diffuse large B-cell lymphoma) of Endometrium extremely rescted to chemotherapy.

子宫内膜恶性淋巴瘤（弥漫性大B细胞淋巴瘤）化疗极度切除一例。

• 发表时间: 2005
• 期刊: Journal of Japan gynecologic oncology 23

Doi D, Ota Y, Konishi H, Yoneyama K, Araki T.: "Evaluation of the neurotoxicity of paclitaxel and carboplatin by current perception threshold in ovarian cancer patients."J Nippon Med Sch.. 70・2. 129-134 (2003)

Doi D、Ota Y、Konishi H、Yoneyama K、Araki T.：“通过卵巢癌患者的当前感知阈值评估紫杉醇和卡铂的神经毒性。”J Nippon Med Sch.. 70・2（2003） ）

化学療法が奏功した子宮体部原発悪性リンパ腫(diffuse large B-cell lymphoma)の1例

化疗成功治愈子宫体原发性恶性淋巴瘤（弥漫性大B细胞淋巴瘤）一例

• 发表时间: 2005
• 期刊: 日本婦腫瘍会誌 23
• 作者: 黒瀬垂輔;山口島子;石川温子;土居大祐;米山剛一;小西英喜;他
• 通讯作者: 他

米山剛一, 沖野恵子, 土居大祐, 荒木勤: "婦人科悪性腫よう術後の血栓症発症因子に関する臨床的検討"産婦人科の実際. 52・6. 137-141 (2003)

米山刚一、冲野庆子、土井大辅、荒木勉：“妇科恶性肿瘤术后血栓形成因素的临床研究”妇产科实践52・6。