Strategy of gene therapy against ovarian cancer by using endostatin

在本研究中，我们研究了各种卵巢肿瘤患者血清内皮抑素和VEGF（血管内皮生长因子）水平。[材料与方法]收集14例卵巢癌患者和4例正常人血清，测定血清内皮抑素水平。检测24例卵巢癌患者、23例卵巢良性肿瘤患者和9例正常人血清VEGF水平。所有培生公司都获得了知情同意。[结果]卵巢癌患者血清内皮抑素水平为94.9± 36.4ng/mL，正常人为63.01±17.1ng/mL;卵巢癌患者血清VEGF水平为664.3pg/mL，卵巢良性肿瘤患者血清VEGF水平为307.4pg/mL，正常人血清VEGF水平为311.2pg/mL。卵巢癌患者血清内皮抑素和VEGF水平明显高于正常对照组（P<0.05）。[结论]血清内皮抑素和VEGF水平可作为卵巢癌筛查的有用指标。

In this study, we investigated the serum endostatin and VEGF(vascular endothelial growth factor) levels of the patients with various ovarian tumors. [MATERIALS AND METHODS]To evaluate the serum levels of endostatain, blood samples were obtained from the fourteen patients with ovarian cancers, four normal volunteers. And to evaluate the serum levels of VEGF, blood samples were obtained from the twenty four patients with ovarian cancers, twenty three patients with benign ovarian tumors and nine normal volunteers. Informed concents were obtained by all pearsons. [RESULTS]The serum endostatin level was 94.9±36.4 ng/mL in the patients with ovarian cancers, 63.01±17.1ng/mL in the normal volunteers. The serum VEGF level was 664.3 pg/mL in the patients with ovarian cancers, 307.4 pg/mL in the patients with benign ovarian tumors, 311.2 pg/mLn the normal volunteers. The serum endostatin and VEGF levels in the patients with ovarian cancers were clearly higher than normal volunteers (p<0.05). [CONCLUSIONS]The serum endostatin and VEGF levels can be useful marker for the ovarian cancer screening.