Genetherapy for Head and Neck Cancer using carrier cell-based delivery of replication-selective adenoviral vector

使用基于载体细胞的复制选择性腺病毒载体递送进行头颈癌基因治疗

• 批准号: 21390462
• 负责人: NIBU Ken-ichi
• 金额: $ 11.23万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390462/
• 关键词: 頭頸部癌; 遺伝子治療; アデノウイルス; ミドカイン; siRNA; Gene therapy; midkine; gene therapy; EGFR; VEGF; 制限増殖型; アデノウイルスベクター; シスプラチン; Endostatin

While multimodal treatments have been performed for the treatment of head and neck cancers, the prognoses of the patients with advanced head and neck cancer are still poor. The estimated survival rates of those patients are around 30%. New strategies for the treatment for head and neck cancer are desirable. To address this issue, we developed the midkine promoter-driven replication-selective adenoviral vector containing siRNA for EGFR or VEGF. With this adenoviral vector, synergistic effect of oncolytic adenovirus and inhibition of oncogene via RNA interference is effect.

虽然已经进行了多模式治疗用于治疗头颈部癌症，但是患有晚期头颈部癌症的患者的预后仍然很差。估计这些患者的存活率约为30%。治疗头颈癌的新策略是可取的。为了解决这个问题，我们开发了中期因子启动子驱动的复制选择性腺病毒载体，含有EGFR或VEGF的siRNA。利用该腺病毒载体，可以实现溶瘤腺病毒与通过RNA干扰抑制癌基因的协同作用。

项目成果

E10A, an adenovirus carrying endostatin gene, enhanced anti-tumor effect of metronomic chemotherapy with low dose cisplatin in a xenograft mouse model for head and neck squamous cell carcinoma

携带内皮抑素基因的腺病毒E10A在头颈鳞状细胞癌异种移植小鼠模型中增强低剂量顺铂节律化疗的抗肿瘤作用

• 发表时间: 2011
• 作者: Zainal Adhimi;Xubin Lin;Wenlin Huang;Tsutomu Nakamura;Hiroyuki Yasui;Naoki Otsuki;Ken-ichi Nibu;Masato Fujisawa;Toshiro Shirakawa
• 通讯作者: Toshiro Shirakawa

MULTI-INSTITUTIONAL ANALYSIS OF SOLITARY EXTRAMEDULLARY PLASMACYTOMA OF THE HEAD AND NECK TREATED WITH CURATIVE RADIOTHERAPY

• DOI: 10.1016/j.ijrobp.2010.11.037
• 发表时间: 2012-02-01
• 期刊: INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
• 影响因子: 7
• 作者: Sasaki, Ryohei;Yasuda, Koichi;Yamada, Syogo
• 通讯作者: Yamada, Syogo

Indications of elective neck dissection and postoperative radiotherapy for parotid cancers

腮腺癌择期颈清扫术及术后放疗的指征

• DOI: 10.5981/jjhnc.37.78
• 发表时间: 2011
• 期刊: Toukeibu Gan
• 作者: 柴田智久;米澤宏一郎;森本浩一;山下大介;大月直樹;西村英輝;佐々木良平,丹生健一
• 通讯作者: 佐々木良平,丹生健一

Post-operative radiation therapy for locally advanced hypopharyngeal carcinoma

局部晚期下咽癌术后放射治疗

• DOI: 10.5981/jjhnc.37.62
• 发表时间: 2011
• 期刊: Toukeibu Gan
• 作者: 西村英輝、佐々木良平;吉田賢史;宮脇大輔;大月直樹;斉藤幹;清田尚臣;副島俊典;杉村和朗;丹生健一
• 通讯作者: 丹生健一

Four cases of spinal accessory nerve passing through the fenestrated internal jugular vein

• DOI: 10.1007/s00276-011-0875-x
• 发表时间: 2012-05-01
• 期刊: SURGICAL AND RADIOLOGIC ANATOMY
• 影响因子: 1.4
• 作者: Hashimoto, Yuriko;Otsuki, Naoki;Nibu, Ken-ichi
• 通讯作者: Nibu, Ken-ichi